... that induced by heatstress and induces HSF1 DNA-binding and transcrip-tional activity [68].To induce transcription, direct interactions betweenHSF1 and components of the transcriptional machin-ery ... [91–93]. Recently, Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, was reported tointeract with the enriched in proline, glutamate, serine and threonine (PEST) sequence of HSF2, which coulddirect ... during mitosis and to enhance the DNA-bindingcapacity of HSF2 [96,98]. However, another reportshowed that the modification rather hinders the DNA-binding activity of HSF2, without interfering...