Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

... FEBS 45 MINIREVIEW Regulation of matrix metalloproteinase activity in health and disease Elin Hadler-Olsen, Bodil Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen and Jan-Olof Winberg Department of Medical ... (2005) Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity,...

Ngày tải lên: 15/03/2014, 00:20

... elec- trophoresis. Increasing the concentration of 2A2 mAb at a fixed molar ratio of cathepsin B and cystatin C resulted in weaker bands of the cathepsin B ⁄ cystatin C complex and stronger bands corresponding ... other cysteine proteases (e.g. papain and cathepsin L) [31]. Removal of the occluding loop contacts results in a dramatic increase in endopeptidase activity, sug...

Ngày tải lên: 18/02/2014, 11:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... HSF4-binding regions and of the transcriptional status of genes located around the HSF4-binding regions. This result is thus suggestive of a structural effect of HSF4 on chroma...

Ngày tải lên: 18/02/2014, 04:20

... define the operation of adjoining. Consider the adjoining of/ ~ at the node marked with * in a. The subtree of a under the node marked with * is excised, and/ 3 is inserted in its place. Finally, ... expressions used in LFG and the elementary trees of TAG. I.I OUTLINE OF THE PAPER In Section 2, we will define briefly the TAG for- malism, describing some of the key...

Ngày tải lên: 21/02/2014, 20:20

... property of not only the compounds in this series but also of other linear inhibitors [44]. The positioning of the inhibitor in the active site results in a tight interaction between the inhibitor’s ... A ˚ on one of the sides leading to loss of the interaction with O of Gly127 but instead making contact with C and O of Gly149. Optimization of the P2/P2¢ side chains Th...

Ngày tải lên: 08/03/2014, 02:20

... release of cytochrome c from mitochon- dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3, the phosphoserine ⁄ threonine binding proteins in ... exist in living cells and casp- ases are indispensable for the proliferation of some cell lines. When deciding between maintaining cells alive or inducing apoptosis, caspase functi...

Ngày tải lên: 14/02/2014, 22:20

... that induced by heat stress and induces HSF1 DNA-binding and transcrip- tional activity [68]. To induce transcription, direct interactions between HSF1 and components of the transcriptional machin- ery ... [91–93]. Recently, Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, was reported to interact with the enriched in proline, glutamate, serine and threonine (PEST) seq...

Ngày tải lên: 18/02/2014, 04:20

... designated A and B, originating from the A and B chains in the structure. dTTP binds at the site of the protein shown previously to bind the nucleotides dUTP and dCTP in wild-type and the E138A ... substrate and inhibitor for binding to the same site [12]. We have previously determined the structures of wild-type dCTP deaminase in complex with dUTP and the inactive E138A...

Ngày tải lên: 18/02/2014, 16:20

... ed-end actin and determine the level and distr ibution o f F -actin [34]. Therefore, it i s tempting to speculate that interactions between monomeric G-actin and actin-binding proteins are a ... fixed, permeabilized and stained for F-actin with rhodamine-conju- gated phalloidin. Th e effects of toxin B and latrunculin B on the actin filaments was examined by preincubating the cells w...

Ngày tải lên: 19/02/2014, 16:20

... published on PEVK domain-containing titin frag- ments (see Introduction for references). The PEVK domain remains the main actin-binding candidate identified in the I-band titin region and we propose, ... entire length of thin filaments and is capable of modulating the r ate of formation of the a ctin– myosin complex [74,75]. Interestingly, nebulin also interacts with the titin PEV...

Ngày tải lên: 19/02/2014, 16:20