Báo cáo khoa học: The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites docx

... ª 2011 FEBS 763 The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites Gre ´ gory ... homo-oligomer in vivo To complete the characterization of the subcellular organization of the epidermis- located steps of MIA biosynthesis,...

Ngày tải lên: 15/03/2014, 00:20

... role in controlling the binding specificity of the N-terminal transactivation domain of p53. Indeed, the p53 phosphorylated by VRK2B shows a reduction in ubiquitination by Mdm2 and an increase in ... determined by their subcellular localization and the proteins present in the corresponding compartment, and by their C-terminal domain, which mediates inter- actions with d...

Ngày tải lên: 30/03/2014, 11:20

... that the combined sys- tem only improves the performance of the parser f or small training sets. Sur- prisingly, the size of the unannotated corpus has little effect due to the noisi- ness of the ... (without Collins) are given in the first lines. # is the size of the test set. The baselines are 73.1% (RC) and 51.4% (PP). The combined method performs better for...

Ngày tải lên: 20/02/2014, 12:20

... endotra- cheal tubes, intravenous lines and chest drains, but not after insertion of nasogastric tubes. In addition, CXRs were obtained in the case of worsening of oxygenation. As a rule, no routine CXR was ... in case of unex- pected infiltrates on the CXR; repositioning of tubes in case of malposition of orotracheal tubes (ignoring planned extuba- tions); ultrasoun...

Ngày tải lên: 25/10/2012, 10:39

... confirmed by Lin-54 bind- ing to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86]. ChIP experiments on the Cdc2 gene also provided insights into the association of other cell ... proteins with the promoter. E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85]. Another E2F site distal to the E2F ⁄ CDE acts as an ac...

Ngày tải lên: 16/02/2014, 09:20

... of the precise residues and interac- tions involved in the NTD–CTD interface [46]. Most of these involve side chains from helix 8 of the CTD which pack against the N-terminal end of helix 4 of the ... of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD of...

Ngày tải lên: 18/02/2014, 06:20

... of both the CAI peptide and a-helix 9 of CTD during formation of the peptide– protein and protein–protein complexes. These NMR experiments also allowed the determina- tion of the CTD binding site. ... (allosteric) effect of CAI binding on the assem- bly of the immature capsid lattice, but a direct binding effect in the conserved CTD binding pocket during mature ass...

Ngày tải lên: 18/02/2014, 06:20

... that the BMPR-IA binding site of the related BMP-7 largely coincides with the noggin-binding area [32,42]. Thus, the proBMP-2 binding to noggin detected here indirectly confirms the interaction of proBMP-2 ... to the ECD of BMPR-IA. Furthermore, the results indicate that both proteins interact with the same epitope on the ECD because proBMP-2 binding can be inhibited by...

Ngày tải lên: 18/02/2014, 06:20

... upregulation in the liver of streptozotocin-induced diabetic rats and the suppres- sion of such elevation following insulin injection [21,22], we decided to investigate the effect of N H CH 2 CH COOH NH 2 L-kynurenine CHO COOH COOH NH 2 Tryptophan α-amino-β-carboxymuconate-ε-semialdehyde ... numbers. The alternative conformations of the Trp–Met couple can be observed; the...

Ngày tải lên: 18/02/2014, 06:20

... polymorph a-chitin (antiparallel packing of the chitin chains); b-chitin (parallel packing of the chitin chains); and the minor polymorph c-chitin (mixture of parallel and antiparallel chain packing) [1,2]. ... show the general importance of chitin-binding proteins in chitin turnover, and provide the first example of a family 33 chitin-binding protein that increases chiti...

Ngày tải lên: 18/02/2014, 08:20