Báo cáo khoa học: Dopamine D4 receptor oligomerization – contribution to receptor biogenesis doc

... mutant receptors influ- ences receptor biogenesis expression. The dopamine receptor family can be subdivided into the dopamine D 1 -like receptor subfamily compris- ing the dopamine D 1 receptor ... max] [Receptor- YFP]/ [Receptor- Rluc] 0.02 0.00 05 D 2L R-Rluc/eYFP D 2L R-Rluc/D 2L R-YFP D 4.7 R-Rluc/D 4.7 R-YFP D 4.4 R-Rluc/D 4.4 R-YFP D 4.2 R-Rluc/D 4.2 R-YFP D 4.2 R-Rluc/...

Ngày tải lên: 14/03/2014, 23:20

... to define exactly which items count as be- ing of 'the same type'. If the definition is too strict, not all cases of contrast will be accounted for. On the other hand, if it is too ... be normally deaccented due to given- ness. This shows that the presence of an alternative item is not sufficient to trigger contrast accent. 519 Another approach to contrastive accent i...

Ngày tải lên: 22/02/2014, 03:20

... tree -to- string translation due to decoding on incorrect source parse trees. To ad- dress the parse error issue in tree -to- string transla- tion, a natural solution is to use n-best parse trees instead ... is how to generate its <T sim > at the decoding time. In practice, it is almost intractable to directly reconstructing <T sim > in advance as in- put for decoding...

Ngày tải lên: 17/03/2014, 00:20

... at top 5, top 10, top 20 and top 30 documents of these system. 4.2 Results and Analysis Altogether, 45 TREC topics (62 queries in all) are chosen for English information retrieval. 712 documents ... likely to cover the most interesting topics for each participant. Initially, each participant would freely choose some topics (typically 5 TREC topics and 5 HTRDP topics). Each query o...

Ngày tải lên: 17/03/2014, 04:20

... "segregatory" and "combinatory" use of conjunctions [Quirk et al., 1982] (e.g. "fly and mosquito repellants" could refer to 'fly' and 'mosquito repellants' ... working on the sentence structure to improve it, looks a lot like a blackboard system architecture. Therefore, one of the future ventures could be to try to look into so...

Ngày tải lên: 23/03/2014, 20:20

... of receptors (D 1 MUT–CFP ⁄ D 1 –YFP, D 2 –CFP ⁄ D 2 R 1– YFP, D 2 –CFP ⁄ D 2 R2–YFP, D 2 –CFP ⁄ D 2 R3–YFP) and with dopamine D 2 and genetic variant dopamine D 1 receptors (D 1 MUT–CFP ⁄ D 2 –YFP) ... combinations (D 1 –CFP ⁄ D 2 –YFP, D 1 –CFP ⁄ D 2 R1–YFP, D 1 –CFP ⁄ D 2 R2–YFP, D 1 CFP ⁄ D 2 R3–YFP, D 1 MUT–CFP ⁄ D 2 –YFP, D 1 –CFP ⁄ D 1 –YFP, D 1 MUT–CFP ⁄ D 1 –YFP, D 2 –CFP ⁄ D...

Ngày tải lên: 07/03/2014, 03:20

... research [1]. According to the classical view of hormone–recep- tor interaction, a hormone binds to one receptor protein and, in turn, the hormone receptor complex activates the effector pathway. A large ... oligomeric a-factor receptors function in concert to activate G-proteins. Further support for the 2 : 1 receptor ⁄ G-protein coupling stoichiometry comes from experiments perfo...

Ngày tải lên: 16/03/2014, 22:20

... b2-adrenergic receptor, because a specific peptide receptor interaction at one site may modulate the ability of the receptor to form dimers at a different interface. Last but not least, it is important to ... these two methods together with CMA [60,67] was applied to the chemokine receptor family to predict a specific interface of dimerization in the chemokine receptor correspon...

Ngày tải lên: 16/03/2014, 22:20

... Myc-tagged extracellular domain of RPTPa ( 1–1 41), together with the transmembrane region and the intracellular domain of LAR (1235–stop), CD45 (426–stop) or RPTPl (865–stop). Mutants were made by site directed ... likely to be due to their ectodomains. To investigate the role of the cytoplasmic domain in dimer- ization we generated RPTPa ectodomain (EDa) ⁄ RPTP chimeras and found th...

Ngày tải lên: 18/02/2014, 17:20

... of the Torpedo nico- tinic acetylcholine receptor. FEBS Lett 423, 22 3–2 26. 17 Xie Y & Cohen JB (2001) Contributions of Torpedo nicotinic acetylcholine receptor cTrp-55 and dTrp-57 to agonist ... localized to the a–c and a–d subunit interfaces. We investigated the involvement of amino acids lying at an adjacent interface (c–a) in receptor properties. Recombinant Torpedo recept...

Ngày tải lên: 19/02/2014, 07:20