Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf

... 2011 The Authors Journal compilation ª 2011 FEBS Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a Fiona M. Keane 1 , ... important physiological substrate of FAP endopeptidase activity. This study reports the first natural substrates of FAP dipeptidyl peptidase activ- ity. Neuro...

Ngày tải lên: 14/03/2014, 23:20

... neurotransmitter fibers, specifically vasoactive intestinal peptide (VIP), CGRP, SP and NPY. Bones of the calvaria also receive a rich supply of sensory, sympathetic and parasympathetic innerva- tions ... also provided [16]. In this study, sensory fiber-associated neuropeptides, calcitonin gene-related peptide (CGRP) and substance P (SP) were first observed at embryonic day 21 i...

Ngày tải lên: 18/02/2014, 04:20

... ovary; cNPY, chicken neuropeptide Y; cPP, chicken pancreatic polypeptide; cPYY, chicken peptide YY; Hsa, Homo sapiens chromosome; pNPY, porcine neuropeptide Y; PP, pancreatic polypeptide; pPYY, porcine ... aliquoted and stored at )80 °C. Peptides and nonpeptide ligands Chicken PYY and PP were ordered from Schafer-N (Copenhagen, Denmark). For the studies of Y 6 , pNPY and pPYY...

Ngày tải lên: 19/02/2014, 07:20

... concept is sup- ported by a number of histological studies revealing the existence of neuropeptide fibers and neuropeptide Keywords amidated neuropeptide; bone marrow stromal cells; bone mass; NPY; ... a-amidates peptides, and which is rate-limiting in the process of neuropeptide maturation, as its substrates exist in excess [20,21]. Among the neuropeptides that are amidat...

Ngày tải lên: 15/03/2014, 09:20

... loenzyme. Keywords: phosphoprotein phosphatase; PP2A; subunit interactions; phosphorylation. Protein phosphatase 2A (PP2A) is an abundant cellular serine/threonine-speci®c phosphatase that regulates ... Binding of B56a wild type pr otein to PP2A A was assessed in the presence or a bsence of 1 lg of puri®e d PP2A C and/ or 10 lLof 35 S-labeled PP2A C synthesized in vitro. ( B) GS T-A bo...

Ngày tải lên: 08/03/2014, 10:20

... protections, and solid boxes represent the R3 footprint and the lac operators. The positions of nucleosomes ) 1, 0, + 1 and + 2 are marked. (A) Mapping the posi- tion of the nucleosomes in the presence of ... Simpson RT, Roth SY, Morse RH, Patterton H-G, Cooper JP, Murphy M, Kladde MP & Shimizu M (1993) Nucleosome positioning and transcription. Cold Spring Harb Symp Quant...

Ngày tải lên: 16/03/2014, 10:20

Ngày tải lên: 15/03/2014, 23:20

... C & Volff JN (2006) Tissue- specific expression of dmrt genes in embryos and adults of the platyfish Xiphophorus maculatus. Zebrafish 3 , 325–337. A. Herpin and M. Schartl Sexual development ... Ova-testis Spermatogonia, spermatocytes PCR, IC, western blot [18] Danio rerio G Testis and ovary High in testes Spermatogonia, spermatocytes spermatids and developing oocytes PCR, ISH [2...

Ngày tải lên: 14/02/2014, 19:20

... amino acids (TDPGAGPVAT for GAPDH; MDPGAGPVAT for PGK). P5 C, PGK– 5aa–cerulean; G 5Y, GAPDH–5aa–citrine; P7 C, PGK–7aa–cerulean; G 7Y, GAPDH– 7aa–citrine; P1 0C, PGK–10aa–cerulean; G1 0Y, GAPDH–10aa–citrine. ... the whole area (in the case of cell samples without coexpression of GAPDH) or from the cytoplasmic area (in the case of cell samples with coexpression of GAPDH) of ce...

Ngày tải lên: 16/02/2014, 09:20

... by phosphorylation of serine 9. This could be explained by overexpression of cellular phosphatases that are able to interfere with these signaling pathways, for example, PP2A. The phosphatase PP2A ... phos- phorylation of the C-terminal domain-tail of the largest subunit of RNA polymerase II at serine 2 and 5; phos- phorylation of DSIF (converts DSIF into an activator); and...

Ngày tải lên: 16/02/2014, 14:20