... either PKCa or PKCe in the antisenseorientation, producing a reduction of the expression of PKCa and PKCe, respectively. Reduced expression of PKCa and/ or PKCe did not modify the response of the kinase ... have therefore studied the d irect and receptor-mediated activation of PKC in a cellular model of downregulation o f PKCe and/ or PKCa to understand the respective roles of these specific isoforms ... onditionedmedium of cell cultures, human plasma and in the cerebrospinal fluid. Other enzymes, b-andc-secretase,cleave APP at the N and C termini of Ab, respectively,releasing the amyloidogenic...