Báo cáo khoa học: "REFLECTIONS ON 20 YEARS OF THE ACL AN INTRODUCTION" pptx

... being one for ceremony and celebration. Vic, Dave, Martin, Warren, Joyce, Bob Simmons, Bill, Aravind, Stan, Paul, Jon, Ron, Bonnie, and Norm agreed to Join me on the panel. Jane refused on the ... name to the Association for Computational Linguistics in 1968, but that did not affect the continuity of the organization. The date of this panel, 17 June, misses the re...

Ngày tải lên: 08/03/2014, 18:20

... these issues, Certainly an important contribution of computa- tional linguistics is the provision of instru- mental means to acquire data, In my view, the study of both speech synthesis and ... P~FLECTIONS ON TWENTY YEARS OF THE ACL Jonathan Allen Research Laboratory of Electronics and Department of Electrical Engineering and Computer Science Massachusetts I...

Ngày tải lên: 17/03/2014, 19:21

... dependent on the strength of the Fe-His bond and hence on the status of the proximal His H-bond. It appears that one can readily rationalize the general trends but not the magnitude of the chan- ges ... with other proximal residues in the core of the enzyme. Although the mutation induces no significant changes to the functional properties of the enzyme, el...

Ngày tải lên: 07/03/2014, 21:20

... confor- mation change, then allowing the purine base to bind in accordance with the mechanism of human HPRT [19,25]. This conclusion can be made based on the lack of thermal shifts when only the ... crystal contacts [24]. The bound phosphate ion superposes well with one of the phosphates of pyrophosphate in the transition state analog complex of human HPRT with immuc...

Ngày tải lên: 15/02/2014, 01:20

... simi- lar to their human homologues. Both the human and zebrafish T-bet and Foxp3 genes contained the same number of exons and introns. t-bet contained six exons and five introns, whereas foxp3 contained ... at the 3¢ end of the gene, where the zebrafish and human sequences appear to be quite diverse. Together with the well-conserved gene organization, there is a conservation of...

Ngày tải lên: 16/02/2014, 09:20

... 5B) or the S16A and Y26F control mutants (data not shown), thereby con- firming that modification of OTUB1 has an impact on the magnitude of Yersinia invasion. Because no effect on invasion was ... bacterial invasion. The accumulated pool of active RhoA contributes to an enhanced uptake in the early phase of invasion, con- sistent with the involvement of the microt...

Ngày tải lên: 16/02/2014, 15:20

... modifications of the linker histones. Lysine and N-terminus acetylations Acetylation of the Na-terminus involves the cotransla- tional cleavage of a methionine, followed by acetyla- tion of the second ... genomic position, as given in Swiss-Prot and similar databases. Structure and function of the linker histone variants Location and structure of the linker histones His...

Ngày tải lên: 18/02/2014, 08:20

... target of SREBP [20] . The role of SREBP-1a in the regulation of cell growth and the cell cycle might be biphasic and complex, and needs to be further investigated. SREBP is evolutionarily conserved; ... fatty acid. H. Shimano Physiology and pathophysiology of the SREBP family FEBS Journal 276 (200 9) 616–621 ª 200 8 The Author Journal compilation ª 200 8 FEBS 619 conforma...

Ngày tải lên: 18/02/2014, 13:20

... concentrations (0.1–10 lm)ofI C , the membrane association rate con- stants (k a ), dissociation rate constants (k d ), and equi- librium dissociation constants (K D ) for the interaction between the protein and PC-based ... in regulation of the specific binding of I C to the anionic phospholipid membranes (Fig. 4A). The participation of the N-terminal region of bovine PE...

Ngày tải lên: 19/02/2014, 05:20

... subgraph containing all the hub connections, and their interaction partners. One pair of connected proteins is conserved, in the so-called k-scaffold graph, if the degree of at least one protein of ... under-representation of connections between hubs and the overabundance of highly con- nected nodes linked to poorly connected ones (both observed in the correlation profile)....

Ngày tải lên: 19/02/2014, 07:20