Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... of the human and mouse PXR ligand binding domains.By modeling the human PXR ligand binding domain wehave identified and mutated two polar residues in the puta-tive ligand binding pocket which ... built ahomology model of human PXR in order to identify residues that were likely to be involved in ligand binding. Since the initiation of this study the crystal structure of the human receptor ... both adjacent to the ligand binding pocket. The crystal structure of human PXR has shown thatthese residues are also involved in hydrogen bonding interactions with the synthetic ligand SR12813 [23].4898...
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Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx
... Ca of Glu and itscarboxylate oxygen, Ca of Asp a nd its carboxylate oxygen,Ca of Arg and its side-chain amines or guanidinium, and Ca of Lys and its side-chain amine was determined bymeasuring ... of these residues were clustered into nine regions of identity (I–IX). Inspec-tion of these regions showed that residues implicated in Zn2+ binding and catalysis were imbedded in the highlyconserved ... the active site by the interaction of t heN-terminal amine of t he P1 residue with a c arboxylateoxygen of Asp273 (Asp366), the carbonyl oxygen of the P1residue with the side-chain amine of...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
... similarity to type III PKSs, whichlack this domain, is scant. This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetase domain of the PKSs for polyketide biosynthesis ... genes of the A201A biosyn-thetic pathway, may be related to their counterparts of the puromycin and hygromycin A biosynthetic pathways,respectively. The puromycin biosynthetic gene cluster (pur)fromS. ... other proteinsimplicated in the biosynthesis of the aminonucleoside moiety of A201A. Here we report the sequencing of a total of 6946 bp, which include the ata genes most likely implicatedin...
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Tài liệu Báo cáo Y học: Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II ppt
... s erine/threonine protein k inaseswidely expressed in a range of eukaryotes including yeast,mammals and plants. They have been shown to play a role in diverse physiological events including ... CKI may play a role in synaptic vesicle exocytosis.Keywords: CKI; CKII; syntaxin-1A; trafficking.Casein kinase I (CKI) belongs to a family of serine/threonine protein kinases with seven isoforms ... phosphorylationsite(s) w ithin syntaxin 1 A, 2 lg of the c ytoplasmic domain (residues 1–265) or the truncated versions (1–190 and 191–265) of syntaxin 1 Awere tested for their ability to be...
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Báo cáo khóa học: Identification of residues controlling transport through the yeast aquaglyceroporin Fps1 using a genetic screen ppt
... Saccharomyces cerevisiae has four such MIP channels: the aquaporins Aqy1 and Aqy2 and the aquaglyceroporinsFps1 and Y 054 [8]. Aqy1 is a strictly spore -specific aquaporin while Aqy2 may play a role in ... screen for hyperactive Fps1 and isolated mutations in 14 distinct resi-dues, all facing the inside of the cell. Five of the residues liewithin the previously characterized N-terminal regulatory domain ... in the genetic screen reported here. For clarity the N- and the C-termini are not shownaccording to scale. (B) Summary of mutationsaffecting the function of the N-terminal regu-latory domain. ...
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Báo cáo Y học: Identification of the 19S regulatory particle subunits from the rice 26S proteasome potx
... Rpn8 and Rpn11), and described the relationship between N-acetylation and the chymotrypsin-like activity of 20S proteasome. In the present s tudy, we detec ted the N-acetylation of OsRpt6 in the ... 269) 1475Protein assay The protein concentration of the sample was d etermined by the Bradford method [17] using c-globulin as a standard.Western blotting analysis The subunits of rice RP were ... of them in both cytoplasm a nd nucleus of eukaryoteis ubiquitin-proteasome pathway that involves the covalentattachment of polyubiquitins to substrate targeted for degradation. The ubiquitinated...
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Báo cáo Y học: Identification of novel membrane proteins by searching for patterns in hydropathy profiles potx
... fourmembrane-associated domains. These four domains areorganized as a cluster of three closely spaced domains near the centre of the polypeptide, and a fourth well separated domain close to the C-terminal end of the ... designed for the acetylcholine (ACh) and glycine receptors of the cys-loop receptor superfamily. The key feature was a closely spaced triplet of hydropathypeaks bracketed by deep valleys. When ... pattern of peaks in theirhydropathy profiles. (A) The hydropathy profile of a rat dopaminesymporter reveals a pair of peaks followed by a deep valley, then acluster of nine peaks. The peak, base and...
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... 2002terminus that is required for binding to the plasmamembrane, thereby being involved in the formation of the corneum [47]. Additional amino-terminal residues of TGase 1 include the sequences ... catalyses cross-linking between the c-carboxyamide of glutamine residues and the e-amino group of lysine residues or other primaryamine. The reaction leads to the formation of an isopeptidebond ... conserved. The sequences around the GTP- binding region, catalytic site, and Ca2+ -binding region arehighly homologous to the corresponding regions of the human TGase 2 and the other invertebrate...
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Báo cáo Y học: Identification of a critical lysine residue at the active site in glyceraldehyde-3-phosphate dehydrogenase of Ehrlich ascites carcinoma cell ppt
... However, the limitation of the kinetic method for determination of the number of amino-acid residue(s) and also of the stoichiometry of the reaction was indicated byLevy et al. [22]. Therefore the ... value of 9.0due to rapid loss of the enzyme activity of the controlsample. It was observed that for the EAC cell enzyme, the rate of inactivation was increased with the increase in pH of the incubation ... not inactivate the enzyme indicting that this amino acid is not criticallyinvolved in the catalytic activity of EAC cell Gra3P DH.Therefore, we tested lysine -specific reagents on the catalyticactivity...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... glycerol,0.8 mM NaPi,4mM spermidine, and 3 mg poly(dI:dC).Where indicated, 5 pmol unlabelled probe was included in the binding reaction. Binding was performed for 15 min, atthis point ... phosphorylated by the intrinsic Ser/Thr-kinase activity of the activated receptor. Oncephosphorylated, Smads 2/3 bind to the ‘common pathway’Smad 4 followed by translocation of this heterodimer into the ... decrease in SeP. As TGF-b1plays an important role in regulation of in ammatoryprocesses as well as in wound healing, an involvement of the signalling pathway unveiled in our study appears likely.ACKNOWLEDGEMENTS.W....
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