Báo cáo khoa học: Insufficient hydrogen-bond desolvation and prion-related disease ppt

... PAPER Insufficient hydrogen-bond desolvation and prion-related disease Ariel Ferna ´ ndez* Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA A structuring and eventual ... observation, a physico- chemical basis for prion-related molecular diseases is proposed. MATERIALS AND METHODS First, I systematically inspected the desolvation patterns of b...

Ngày tải lên: 08/03/2014, 10:20

... 1185– 1192. Fei Sha and Fernando Pereira. 2003. Shallow parsing with conditional random fields. In Proceedings of HLT-NAACL, pages 134–141. Sajid M. Siddiqi and Andrew W. Moore. 2005. Fast inference and learning ... the n-th column such that y n ∈ I(z n ), and we can use λ(z n ) and ¯ λ(z n ) instead of λ(y n ) and ¯ λ(y n ). We compute λ(y n ) and ¯ λ(y n ) by using the forward...

Ngày tải lên: 07/03/2014, 22:20

... say individual concepts and propositions and not referents and truth values. We bear in mind that a seman- tic network is a graph whose nodes repre- sent individuals and whose oriented arcs ... system can reason about intensional concepts like know- ledge and belief. A problem resolver must understand the concept of knowledge and know for example what knowledge it needs to...

Ngày tải lên: 21/02/2014, 20:20

... favorably with those in (Blaheta and Charniak, 2000). Lintean and Rus (2007a; Lin- tean and Rus (2007b) also studied the function tag- ging problem and applied naive Bayes and decision tree to it. Their ... system performs much better than both (Blaheta and Charniak, 2000) and (Lin- tean and Rus, 2007a). For two major categories, namely grammatical and form/function which ac...

Ngày tải lên: 07/03/2014, 22:20

... Goodenough, 1965; Miller and Charles, 1991), and human judgments have previously been used successfully to study synonymy and near- synonymy (Miller and Charles, 1991; Bybee and Eddington, 2006). ... Rosch and Mervis, 1975), and there are borderline cases on which people disagree more often, and on whose categorization they are more likely to change their minds (Hampton, 1979;...

Ngày tải lên: 08/03/2014, 00:20

... of an accent’s shape (van Santen and M ¨ obius, 2000)), c1 and c2 model the ranges of the rising and falling amplitude of the accent’s contour, respectively, and parameter d expresses the peak ... given and new with pitch ac- cent types L∗H and H∗L. The distributions show a clear trend towards greater similarity form high-frequency “given L∗H” and “new L∗H” to mid-frequency “new...

Ngày tải lên: 17/03/2014, 22:20

... and therefore is independ- ent of the interaction between eIF4E and eIF4G [10,11]. The picornaviral proteinases such as the leader proteinase (L pro ) of foot -and- mouth -disease virus (FMDV) and ... (eIF4GI) and I4G3_human (eIF4GII). (B) Comparison of the C-terminal extensions of FMDV Lb pro , ERAV Lb pro and ERBV Lb pro . Asterisks in (A) and (B) indicate conserved basic resid...

Ngày tải lên: 23/03/2014, 13:20

... the G264V homozygote, and 195 and 227 pgÆmL )1 in the control subjects. Concentration of plasma glycerol at time 0 w as 104.4 lmol ÆL )1 in the G264V hom ozygote, and 55.7 and 97.2 lmolÆL )1 in ... V59L and G264V), and two silent mutations (A103A and G250G). The cRNA injection of the missense mutants into Xenopus oocytes revealed the a bsence of the activity to transport glycero...

Ngày tải lên: 23/03/2014, 21:21

... sig- nalling [3–5] and of cytokines such as interleukin (IL)-6 [6]. It is also involved in transformation and tumour progression [7] and its activation, as detected in breast, head and neck, lung and colon ... control ODN (con) and the dead cells were counted after 16, 24 and 48 h of culture using trypan blue staining. (C) Cells were treated with 0.5, 1 and 2 lg of hpST3dODN...

Ngày tải lên: 18/02/2014, 08:20

... diagnostic and therapeutic schemes. Antisense-RNA, ribozyme, aptamer and siRNA tech- nologies have been developed and have found applica- tion in molecular medicine [1–7]. Signalling aptamers and aptazymes ... as three additional bands (lanes 3 and 4). These signals correspond to the 29- and 35-mer resulting from ligation of the 20-mer to either the 9- or 15-mer cleavage product,...

Ngày tải lên: 20/02/2014, 01:20