Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot

... Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata Tamotsu ... presence of large amounts of docosahexa- enoic acid and that several acyltransferase activities are involved in the process in ye...

Ngày tải lên: 08/03/2014, 08:20

... between the main-chain amides and the polar side chains. The glu- tamine- and asparagine-rich regions are commonly found in the N-termini of both mammalian and yeast prion proteins [96] and several ... con- cluded that domain-swapping may be the rate-deter- mining step [132]. Domain-swapping demands almost complete unfolding before the two chains can rearrange and sw...

Ngày tải lên: 14/02/2014, 18:20

... endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium lining the lacunar spaces of the corpus cavernsoum; and (c) the endocrine milieu that regulates the fibroelastic ... E 2 , contributing further to the decrease in testoster- one concentrations and the preferential accumulation of abdominal fat, leading to androgen...

Ngày tải lên: 18/02/2014, 06:20

... with bovine serum albumin as a standard. Enzyme assays Recombinant NAT1 enzyme activity was determined spec- trophotometrically using PNPA as the acetyl donor and PAS as the arylamine substrate [45]. ... N-acetyltransferases (NATs) are phase 2 XMEs that catalyse the transfer of an acetyl group from acetyl-coenzyme A (AcCoA) to the nitrogen or oxygen atom of primary arylamine...

Ngày tải lên: 07/03/2014, 02:20

... of N-acylposphatidylethanolamine-hydrolyzing phospholi- pase D and reduced activity and expression of FAAH. Both the accumulation of anandamide (and of other N-acylethanolamines) and the protective effects of rimonabant ... Department of Pharmacobiology and University Center for Adaptive Disorders and Headache (UCADH), University of Calabria, Arcavacata di Rende...

Ngày tải lên: 07/03/2014, 03:20

... denaturation, and protein aggregation, protecting the enzyme from denaturation. Mercury-induced inactivation of cholinesterases is thus a rather complex process. Our results indicate that among ... radius increased linearly with mercury concentration. Physical changes and protein aggrega- tion occurred in the first minute after mercury addi- tion, and the size of the aggr...

Ngày tải lên: 23/03/2014, 09:21

... crucial role in the fibrillization process [27]. The results of a systematic alanine-scan of a shorter IAPP fragment (Table 1) indicated that other than phenylalanine, any amino acid within the fragment could ... because of a gradual increase in life expectancy. The genuine understanding of the mechanisms leading to the formation of amyloid fibrils and its in...

Ngày tải lên: 23/03/2014, 11:20

... biogenesis of ApoE-containing HDL with the participation of the lipid transporter ABCA1 and plasma enzyme LCAT. Minimally lipidated ApoE in plasma interacts with ABCA1 (step 1) that is present in the ... circulating ApoE is involved in increased adiposity and obesity-related metabolic disorders. Of note, the uptake of ApoE-lacking VLDL into the liver and adipocyt...

Ngày tải lên: 29/03/2014, 22:21

... continued to produce GFP and remained marked. To analyze the rapid and extensive expansion of the adipose lineage during the first postnatal 30 days (P30), Graff and colleagues [36] treated the LacZ-mice ... both adipose depots and adipocytes. Taken together, the data obtained by Graff and colleagues [36] show that a pool of white adipocyte precursors is established p...

Ngày tải lên: 29/03/2014, 22:21

... leptin, the in ammatory chemokines tumor necrosis factor -a (TNFa) and an array of interleukins, and angiogenic and vasoactive molecules such as vascular endothelial growth factor (VEGF) and angiotensin ... triggers a high degree of insulin resistance and signs of other metabolic dysregulation similar to visceral WAT expansion. The importance of maintaining at least...

Ngày tải lên: 29/03/2014, 22:21