Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx
Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf
... involved in the interaction as the binding of 125 I-labelled DS was reduced to isogenic derivatives of the AP1 strain lacking either of these surface proteins (Fig. 2). The significance of the M1 protein ... shown). Taken together, these results suggest that the interaction between S. pyogenes and GAGs is mediated by M protein. Mapping of the DS binding region in...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... gifts of the MAP2 cDNA and the pCAG expression vector, respectively. The present study was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology; the ... 1657 Discussion The present study revealed the structural and func- tional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e. the M...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... comparison of rhodamine uptake, in the presence and the absence of uncouplers, allows the estimation of the effect of intracellular binding on the MDR phenomenon. The data detailed obtained in the present ... the cell lines tested and the efflux of rhodamines in MRP1 over-expressing cells was abolished by NBD-Cl, it appears that rhodamines are excluded from th...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells doc
... proliferation and cell death [27]. The functional roles of the activation of these kinases are often con- troversially discussed. The ERK1 ⁄ 2 cascade is regarded to be the main method of transmission ... Because many ther- apeutic agents eliminate tumor cells by inducing apop- totic cell death, the further understanding of the apoptotic mechanisms is required for the...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
... corresponding pH-rate profiles. The pK a values of the cofactor phosphate in unliganded EcMalP and the EcMalP–arsenate complex are 5.6 [26] and 6 .7 [27], respectively. The pK a of the 5¢-phosphate group ... in the presence of 5 m M potassium phosphate and potassium sulphate. Reconstitutions with PLP of apo- Cc StP and mutants thereof, and characterization of t...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... [32,37,38]. The variation in the effect of stabilizing osmolytes in modulating the catalytic efficiency of RNase-A in the presence of each class of osmolyte may best be explained by the combination of ... unfavourable interaction between the osmolyte and the peptide back- bone, and (b) the total contribution of side chains to the stability of the nativ...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum pot
... presence of 10, 25, 50, 75 and 120 lm cofactor, and the K m and k cat for AdoCbi-GDP were determined in the presence of 20, 70, 100, 150 and 200 lm cofactor. The reaction was initiated by adding l-glutamate ... energy of the cofactor is sensitive to changes in the pK a of the lower axial base [3]. This has led to speculation that proteins might modulate the pK...
Ngày tải lên: 07/03/2014, 04:20
Báo cáo khoa học: Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 – a molecular link between recombination and chromatin assembly during meiosis pot
... overhang is formed by exonu- clease activity and invades the homologous double- stranded region of the other allele. These steps of homology search and recombination are catalysed by two bacterial ... place between homologous chromosomes of maternal and paternal origin. This is followed by the segregation of maternal and paternal copies of each chromosome. A ph...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Interactions between metals and a-synuclein ) function or artefact? pptx
... be mediated by interaction of Cu with the C-terminus of the protein. This was shown by limited proteolysis of the a-synuclein that cleaved off part of the C-terminus, either at residue 97 or 114. The ... [18,44–52]. The mice either expressed human wild-type a-synuclein or the human protein carrying one of the two main mutants (A53T or A30P). These mice differ in...
Ngày tải lên: 07/03/2014, 10:20
Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... indi- cate a number of links between the activation of p38 kinase and the DNA checkpoint pathways and their possible interaction in the modulation of cell cycle con- trol and DNA mismatch repair ... 2 and of p50 NF-jB1 to the nucleus suggests a role of both proteins in the regulation of cell cycle progression by extracellu- lar nucleotides. Sustained activa...
Ngày tải lên: 07/03/2014, 12:20