Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc
Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot
... systemic haemorrhage in mice. These results emphasize the importance of the rapid homing of RVV-X into microvessels to exert its effect. The glycan structures of a number of venom glycopro- teins ... sequenced. Of these, 10 clones were found to encode the LC2 and LC1 sub- units. Others were found to encode other variants of the C-lectin-like venom proteins. The amino...
Ngày tải lên: 07/03/2014, 06:20
Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc
... the measurement of the rate of passive diffusion of the dye through the plasma membrane. This cannot be done by the simple measurement of the increase of the fluorescence signal (F cyto ) of the ... proportional to the amount of rhodamine free in the cytosol. This observation allows the further determination of the concentration of drug free in the c...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx
... lack of FMRP function as the primary cause of the syndrome. In spite of its key importance, the effect of the I304N mutation on the structure and function of FMRP is still unclear, and there ... investigations of the I304N mutation play a key role in Fragile X research, there is no consensus in the Fragile X field on either the structural or functional consequences...
Ngày tải lên: 30/03/2014, 15:20
Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... facilitates the transfer of the proton from the catalytic Cys pres- ent at the N-terminus of the helix to the His of the dyad [19,50,51]. The first stage of catalysis is mediated by the highly ... at the bottom of the subsite is conserved in ervatamins. Compared to a Ser in the equivalent position of papain, the role of Leu here is to restrict the size...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... antibodies to the subunits of the yeast bc 1 complex indicated on the left side of the blots. The Western blots are shown in panels A and B and the relative amounts of each of the subunits determined ... mutant strain. However, the amounts of core protein 1 and core protein 2 were relatively unaffected. Therefore, the absence of subunit 6 appeared to alter the...
Ngày tải lên: 19/02/2014, 12:20
Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx
... molecules of the cofactor ThDP are bound in the canonical V conformation at the interface between the PYR domain and the PP domain of two subunits of the functional dimer. The main chain oxygen of G421 ... The main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the c-carboxyl group of the side chain of resid...
Ngày tải lên: 06/03/2014, 11:20
Báo cáo khoa học: New insights into evolution of crustacean hyperglycaemic hormone in decapods – first characterization in Anomura pdf
... along the neurons of the XO ⁄ SG system (Fig. 4A). Classically, the X-organ (the grouping of perikarya in which the neuropeptides are synthesized) is located inside the medulla terminalis of the ... separate areas of the XO, as a cluster of five MIH-IR cell bodies was observed near the start of the axonal tract, whereas the others were dispersed among CHH-IR st...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khóa học: Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide doc
... to the affinity of nitrite for the protein site where it is transformed into the nitrating species, in the presence of the phenol. Interestingly, these constants resemble the reciprocal of the nitrite ... portions to the substrate solution during 1 h at 25 °C. Formation of the product was accompanied by the development of a yellow and persistent color in the s...
Ngày tải lên: 16/03/2014, 16:20
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot
... com- plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation of the mechanisms of this ... loss, within affected cells, of the two alleles of a given CCM gene. Loss of one of the alleles (first hit) would be the result of a germline mutation and loss...
Ngày tải lên: 15/03/2014, 10:20
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... exhibit the same pheno- type as the heg mutant fish – that of the dilated heart covered by a single layer of myocardium. The similar- ity of the phenotype in these nonsense alleles suggested that these ... dilated heart phenotype. The myocardium proliferates to a normal number of cells, but instead of building into concentric layers to form the walls of the heart,...
Ngày tải lên: 15/03/2014, 10:20