Báo cáo khoa học: "TAL Recognition in O(M(n2))Time" pptx

... usually contain an N-terminal domain (N-domain) that serves as a docking site for various adaptor proteins [6–10]. ClpA consists of three domains: an N-domain and two ATP-binding domains referred ... N-domain of ClpA by monitor- ing the binding, unfolding and degradation of several different substrates, including short unstructured peptides, tagged and untagged proteins. Inter- estingly, ......

Ngày tải lên: 07/03/2014, 05:20

... carcinomas; IAP, inhibitor of apoptosis protein; JNK, c-Jun NH 2 -terminal kinase; KIP, kinase inhibitor proteins; MEK, MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-activated protein kinase ... Japan Introduction The epidermal growth factor receptor (EGFR) is com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The bi...

Ngày tải lên: 16/02/2014, 09:20

... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy. Proteins 73, ... B, Finet S & Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct...

Ngày tải lên: 18/02/2014, 04:20

... are linked to accessory proteins (e.g. zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial cells [8]. Occlu- din is an  65 kDa phosphoprotein ... Claudins are  22 kDa phosphoproteins that are thought to help maintain high transendothelial electrical resistance. Three types of claudins (claudin1 ⁄ 3, claudin5 and claudin12) are found in ....

Ngày tải lên: 18/02/2014, 11:20

... blood vessels in various tissues and organs, including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch ... family members. By contrast, a pathological increase in the blood supply in the CNS is seen in brain tumors, in particular malignant gliomas. In phase II clinical trials, anti-VEGF...

Ngày tải lên: 18/02/2014, 11:20

... for t-PA-induced intracranial bleeding in mouse models of focal stroke [37]. In this model, co-treatment with the broad-spectrum MMP inhibitor GM6001 effectively reduced intracranial bleeding. More recently, ... metalloproteinases, their inhibitors, and laminin in stroke patients: in uence of different therapies. Stroke 34, 2165–2170. 26 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin...

Ngày tải lên: 18/02/2014, 11:20

... B do- mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. As all components of the PTS, depending on their phos- phorylation status, can interact ... transport protein for glucose uptake); FBA, flux balance analysis (tool to determine the flux distribution in cellular networks, requires steady-state conditions); HPr, histidine-containing protein...

Ngày tải lên: 18/02/2014, 13:20

... code for a single protein. Interestingly, during the initial process of identifying the NR family members in the A. aegypti genome, we predicted two isoforms of AaFTZ-F1, differing only in their ... dis- played in AaHNF-4A in hormone-free media that har- bors a complete balance of amino acids suggests the involvement of amino acids in its regulation. This amino acid induced signal r...

Ngày tải lên: 18/02/2014, 13:20

... synthesized for analysis, extending the number of interactions from 10 to 45, permitting a rigid interpretation in distinguish- ing interacting from noninteracting proteins. One Fig. 1. Schematics ... engineer increased protein–protein interaction stability at will; in particular, the ability to increase stability by kinetic design. For example, by achieving this predominantly by decelera...

Ngày tải lên: 18/02/2014, 13:20

... of Parkin, PINK1, DJ-1 and HtrA2 activity remains to be determined. Parkin can be phosphorylated by a number of kinases including casein kinase 1, protein kinase A, protein kinase C [86] and cyclin-dependant ... pool of PINK1 has been described [16,17]. PINK1 is of great interest to research into mitochondrial dysfunction in PD. PINK1 contains a putative catalytic serine–threonine kinase do...

Ngày tải lên: 18/02/2014, 14:20