Báo cáo khoa học: "Methods and Practical Issues in Evaluating Alignment Techniques" doc

... sites 1 and 2 and involved in bind- ing of adenylic nucleotides and BPG. Our results partially confirm the molecular model- ling, suggesting that effector site 1 is the binding site for Ap 4 A and ... S2), and, in particular, a modification in the interaction of this resi- due with Asp351 (directly involved in Mg 2+ binding) and His352 both belonging to motif III. Remarkably,...

Ngày tải lên: 15/02/2014, 01:20

... Chalfont, Buckinghamshire, UK) were used as standards. Protein bands were visualized by staining with Coomassie Brilliant Blue R-250 or silver staining as described [69]. Protein was determined by ... produce and maintain significant levels of glutathione [11] and, interestingly, also contain MAPEG members [1]. Glutathione was observed in various species within the two groups, among those...

Ngày tải lên: 19/02/2014, 17:20

... best-performing results across the N-GRAM fea- tures and their combinations. In each case, our base- line is the majority class in the training set. 3.1 Subjectivity Among all the lemmatization settings, ... difference in data sets and tagging granu- larity. 5 Conclusion In this paper, we build a sentence-level SSA sys- tem for MSA contrasting language independent only features vs...

Ngày tải lên: 20/02/2014, 05:20

... of tokens and average type frequencies in text sections. We reserved patent data published between 1979 and 2007 for training and documents pub- lished in 2008 for tuning and testing in SMT. For ... error rate training In contrast to task pooling and task mixtures, the specific setting addressed by multi-task minimum error rate training is one in which the generative train...

Ngày tải lên: 22/02/2014, 03:20

... will be pointed out below. In contrast with the common use in computational linguistics, 9in this model morphology is essentially static . By interpreting morphology as relations within the ... system usin B indexed sequential and direct access files. In its present implementation, on a VAX-750, words and morphosyntactic elements are stored in indexed sequential files, lex...

Ngày tải lên: 22/02/2014, 09:20

... of parsers are trained by changing the randomization seeds but having the same base parser and using the same training set. They no- ticed that parsers trained using different randomiza- tion seeds ... concate- nation baseline. In particular, Switching:Max could gain up to 2.2 BLEU points over the concatenation baseline and 0.39 BLEU points over the best per- forming baseline (i.e. line...

Ngày tải lên: 19/02/2014, 19:20

... protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine kidney; MEF, mouse embryonic fibroblast; MEK, MAP kinase/ERK kinase; ... accurately explain insulin-stimulated changes in the concentration of intracellular species and partitioning of glucose disposal in skeletal muscle. Insulin propagates a rather complex coo...

Ngày tải lên: 14/02/2014, 14:20

... proteins con- taining methyl binding domains (MBDs) which assem- ble complexes containing repressive HMT and DNMT proteins that act in a concerted fashion to maintain both DNA methylation and H3-K9 ... modification and are maintained in a constitutively active state by CXXC domain proteins that bind to non-methylated CG sequences. These proteins include MLL1 and the CG-binding prot...

Ngày tải lên: 14/02/2014, 18:20

... repressing the indicated targets and presumably hundreds of other as yet unidentified targets. (B) miR-34a and the miR-34a-binding site in the 3¢ UTR of genes shown in (A). miRNAs and cell signaling ... miR-17- 5p and miR-20a are induced in a manner that depends on cyclin D1 and repress the expression of cyclin D1. Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback loop an...

Ngày tải lên: 14/02/2014, 19:20

... numbers in the ‘binding sites’ column represent the distance (bp) between the stop codon and binding sites of seed sequences in the miRNAs. The letters ‘c’ and ‘p’ with respect to miRNA binding site ... melanoma and acute lymphoblastic leukemia [31–34]. In breast cancer, the miR-9-1 locus is highly methylated not only in invasive ductal carcinoma, but also in ductal carci- nom...

Ngày tải lên: 14/02/2014, 19:20