Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... speci c and potent HAD inhibitors. To check for covalent modifications of the enzyme, the effect of the inhibitor on the molecular mass value of HAD was measured; instead of an adduct increase, ... periods. Deamidation of any one of the 17 Asn and Gln sites of RNase A produces a 1 Da increase in the mass, –CO-NH 2 fi –CO-OH, of the molecular ions of that pr...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx
... each of which consists of a sequence of Words. sible for an adaptor grammar to generate a sentence as a sequence of collocations, each of which con- sists of a sequence of words. These collocations ... generates a Sentence as a sequence of Colloc(ations), each of which is composed of a se- quence of Words, each of which in turn is composed of a sequence of Syll...
Ngày tải lên: 20/02/2014, 09:20
Báo cáo khoa học: A simple in vivo assay for measuring the efficiency of gene length-dependent processes in yeast mRNA biogenesis doc
... 0.8–1. Acid phosphatase activity of intact cells was assayed as described [19]. The acid phos- phatase activities of the transformants were corrected by M. Morillo-Huesca et al. Assay for gene length-dependent ... of the two THO mutants were dramatically reduced when compared with the wild type (Fig. 6). The absence of effect of cdc40D and cus2D on the GLAM ratios...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase l isoform pdf
... backbone and the molecular surface of nuclear domains A and B (see the text) are coloured green and blue, respectively. The FAD cofactor is shown as red sticks. The figure was produced by using GRASP ... substanti- ate the hypothesis that these two structural regions are mandatory for the nuclear localization of mSMOl ,as the only difference between mSMOl and mSMO...
Ngày tải lên: 07/03/2014, 17:20
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... translo- cation of Bax from the cytoplasm into the mitochon- dria, cytochrome c release and cleavage of caspase-3 were all observed (Fig. 4B–D). To confirm the involvement of Bcl-2 and caspase-3 in ... mitochondria was increased. Subsequently, cyto- chrome c release and caspase-3 cleavage were observed. TZD-induced adipocyte apoptosis could be blocked by the caspase-3 i...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism docx
... sampled at these positions [9]. Such choices may focus the search of sequence space on areas with a higher frequency of success and thus increase the probability of their detection. In principle, ... selections of Methanococcus jannaschii CM (MjCM) [14] were used to assess the tolerance of a protein fold to secondary structures of varying sequence [15]. MjCM belongs to th...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx
... 5. Construction and purification of MCAK184 (A) Schematic representation of the truncated form of the human MCAK con- struct. The homology domain is a ‘clone-14’ sequence. This con- struct was ... by PCR (forward primer: 5¢-ATGGC CATGGACTCGTCGCT-3¢, reverse primer; 5¢-TCACTG GGGCCGTTTCTTGC-3¢). The neck and motor domains of MCAK cDNA (550–1770), conjugated with NdeI and X...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: "A High-Accurate Chinese-English NE Backward Translation System Combining Both Lexical Information and Web Statistics" pdf
... ofContext ( Where NCT r and NC i denote the appearing times of the rth context CT r and the candidate C i in the returned snippets respectively, and NPT i denotes the total number of ... different cases of the context of C i . Since we want to normalize the entropy to 0~1, we take NPT i as the base of the logarithm function. While concerning...
Ngày tải lên: 20/02/2014, 12:20
Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
... absence and pres- ence of ibuprofen (final concentration, 1.0 · 10 )7 to 1.0 · 10 )2 m). The excess of NO was pumped off gently before recording of ligand dissociation kinetics [20]. The kinetics ... the removal of domain I from HSA does not significantly affect the functional and structural properties of domains I and II [i.e. of the 1–382 region of (t)HSA]. l Th...
Ngày tải lên: 06/03/2014, 01:20
Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx
... pro- tection from nonspeci c damage. This can occur because of the rapid reaction of thiols with many of the damaging species present in biological systems. Furthermore, because many of these ... quench correction. Samples of the [ 3 H] GSH stock solution were measured to determine its speci c activity. Acknowledgements This work was supported by the Medical Research Counc...
Ngày tải lên: 06/03/2014, 09:22