Báo cáo khoa học: Optimization of P1–P3 groups in symmetric and asymmetric HIV-1 protease inhibitors pptx

... of the protease [23–25]. We here report crystallographic studies of C-terminally duplicated C2 -symmetric and asymmetric inhibitors in complex with the HIV-1 protease. These compounds, including ... approved six inhibitors: ampre- navir, indinavir, lopinavir, nelfinavir, ritonavir and saqui- navir [10]. The side effects of these inhibitors and the clinical emergence...

Ngày tải lên: 08/03/2014, 02:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... HSF4-binding regions and of the transcriptional status of genes located around the HSF4-binding regions. This result is thus suggestive of a structural effect of HSF4 on chroma...

Ngày tải lên: 18/02/2014, 04:20

... define the operation of adjoining. Consider the adjoining of/ ~ at the node marked with * in a. The subtree of a under the node marked with * is excised, and/ 3 is inserted in its place. Finally, ... expressions used in LFG and the elementary trees of TAG. I.I OUTLINE OF THE PAPER In Section 2, we will define briefly the TAG for- malism, describing some of the key...

Ngày tải lên: 21/02/2014, 20:20

... flank lengths of 0–12 bases in KCl. We observed enhance- ment of fluorescence intensity on increasing the con- centration of the complementary strand, indicative of a greater extent of quadruplex opening. ... intensi- ties of the initial and final states of titration, respectively, and a b is the mole fraction of quadruplex in duplex form. Assuming 1 : 1 stoichiometry for...

Ngày tải lên: 07/03/2014, 02:20

... processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the protein- ase and involves the HPX domain. A DNA-binding domain was found in the ... illustrated in Fig. 2B (step 1). Interactions with small integrin-binding ligand N-linked glycoprotein (SIBLING) Individual members of the SIBLING family are known to bind strongly to...

Ngày tải lên: 15/03/2014, 00:20

... extracellular surface and involved in the decrease in E h would be of interest for increasing our understanding of the mechanisms involved as well as the reducing activity of L. lactis. A Gram-positive ... reducing metabolisms. L. lactis is able to maintain a low E h7 until the end of fermentation and for 24 h [16]. The role of the active mechanisms in maintaining a low re...

Ngày tải lên: 22/03/2014, 21:21

... estimation of the spectra of intermediates, of rate constants, and of the con- centration of intermediates as a function of time. The same program was used to simulate kinetic processes [35]. Of relevance ... gÆL )1 glucose, 1 mml-glutamine, 1 mm sodium pyruvate, and penicillin ⁄ streptomycin, and then exposed to increasing concentrations of DAAO and d-Ala for 24 h. Fo...

Ngày tải lên: 16/03/2014, 02:20

... the main effect of transamination is a reduction of the degre e of 15 N-labelling in the amino a cid of interest. In thecaseof[ 15 N]Gly, much of the label appeared to have been trapped in an ... enzyme inhibitors. This would provide the benefit of less isotopic dilution and thereby improved labelling efficiency and enhanced sensitivity of the NMR analysis. In the abs...

Ngày tải lên: 16/03/2014, 18:20

... importance of the detergent in preparing a stable monomeric ectodomain of a class A pen- icillin-binding protein. Our assay could be used to screen collections of compounds for inhibitors of peptidoglycan ... cross- linked through short peptide chains. Peptidoglycan assembly is catalyzed by the periplasmic domain of bifunctional class A penicillin-binding pro- teins. Cross-linki...

Ngày tải lên: 29/03/2014, 21:20

... consists of the rapid binding of the N-terminus of the partner, regardless of whether it is a twin-arginine signal peptide or not, followed by its release once cofactor loading and protein folding ... only minor confor- mational changes upon binding the twin-arginine signal peptide of NapA [18]. In this case, biogenesis of the NapA protein is assisted by NapF in charge of...

Ngày tải lên: 16/02/2014, 14:20