Báo cáo khoa học: Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini Formation of CrkII–protein complexes docx

... Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini Formation of CrkII protein complexes Alberto G. Andreolotti 1 , Maria ... activation of the G-protein coupled CCK A receptor in vivo in rat pancreatic acini promotes the function of CrkII, resulting in complex formation (CrkII paxillin and CrkII p130 Cas )....

Ngày tải lên: 07/03/2014, 21:20

... occurred mainly in protein complexes of approximately 2 MDa (fraction 16). The same fraction contained only very low levels of RxRa in comparison to PPAR b, indicat- ing that these complexes are ... starved for 45 min in methionine ⁄ cysteine-free DMEM (Invitrogen, Karlsruhe, Germany) containing 1% glutamine and 5% dialyzed fetal bovine serum, and incubated with 430 lCi of Red...

Ngày tải lên: 30/03/2014, 03:20

... regulation of apoptosis. In this study, we identified two distinct domains in the N-terminal region of Scythe capable of binding Xrpn10c redun- dantly: Domain I and Domain II. Domain I contains a typical ... domains in both Domain I and Domain II are involved in targeting of Scythe to Xrpn10c in vivo. These results indicate that Scythe is a novel protein that contains functi...

Ngày tải lên: 30/03/2014, 11:20

... of a novel option for accessory cancer therapy involving the combined use of vitamin D and epigenetic modifiers. This strategy also has the advantage of the use of low concentrations of vitamin ... open chromatin structure to facilitate the binding of major transcription factors on the promoter. We were therefore interested in determining whether TSA ⁄ - NaBu had any effects on p...

Ngày tải lên: 22/03/2014, 21:20

... following a trend set in Australia. The medical literature is now rapidly growing as well, but it has been focused almost exclusively on either the benefits of METs in terms of reducing unexpected mortality ... Care Medicine and Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Corresponding author: Michael DeVita, devitam@upmc.edu Pub...

Ngày tải lên: 25/10/2012, 10:45

... dis- tribution of mutants defective for RNA binding. Point mutations disrupting the RNA-binding capacity of any of the two RRMs led to the nuclear sequestration of the reporter protein, confirming the inability ... the abundance of each ARE-BP [53]. Interestingly, the down-regulating effect of ASF ⁄ SF2 is preserved upon inactivation of its RNA-binding ability by point muta- tion...

Ngày tải lên: 16/02/2014, 15:20

... Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev 25, 99–113. 45 Stetler-Stevenson WG (2008) Tissue inhibitors of metal- loproteinases in cell signaling: metalloproteinase-inde- pendent ... regarding the role of the aVb3 integrin, because it is also reported to suppress collagen I-induced activation of proMMP-2 [8]. Another MMP inhibitor, reversion-inducing cystein...

Ngày tải lên: 18/02/2014, 11:20

... Polonsky KS (1993) Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab 76, 44–48. 25 Baker ... have distinct domain organizations and physiological func- tions: insulin is a heterodimeric peptide consisting of an A-chain and a B-chain, whereas IGFs are single- chain peptides with do...

Ngày tải lên: 18/02/2014, 13:20

... December 2008) doi:10.1111/j.1742-4658.2009.06866.x l-Canavanine occurs as a toxic non-protein amino acid in more than 1500 leguminous plants. One mechanism of its toxicity is its incorporation into proteins, replacing l-arginine and giving rise to functionally ... soybean. When binding of arginine in the presence of tRNA was investigated, some changes in the binding architecture...

Ngày tải lên: 18/02/2014, 13:20

... successful examples of binding-sequence discrimination, the native sequences of the RRM1 of Sex-lethal protein (1B7F_1) and KH1 domain of Poly C-binding protein-2 were both ranked first out of 256 sequences, ... for predicting the specificity of RNA-binding proteins and to evaluate the contribution of individual amino acids to the energetic of protein–RNA complexes. Knowledge-...

Ngày tải lên: 18/02/2014, 16:20