Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt
Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt
... Rathinavelan and N. Yathindra4070 FEBS Journal 272 (2005) 4055–4070 ª 2005 FEBS Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene Stereochemical ... destabilization and hence, diminution of the melting temperature (Tm) in the former.Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexesIntra strand base stacking at the AC(6–7) ... tointerrupted stacking, fluctuating nature of the hydro-gen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free energy and diminished stability...
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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... Ca2+.Removing the proposed Ca2+-coordinating residues in positions 1 and 3 of the EF-hand motif significantlycompromised the metal-binding capability of the engi-neered protein, indicating that the ... grafting approach to address thisquestion. As shown in Fig. 1B, the distance between the two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within15 ... the initial mixture. The fluorescence intensity wasnormalized by subtracting the contribution of the baselineslope using logarithmic fitting. The Tb3+-binding affinity of the protein was obtained...
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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... relaxin-3 in the brain, and particularly its functions, including the stress response and food intake, are described.Expression of relaxin-3 in the brainRelaxin-3 neurons in the brainExamination ... contains the RXXXRXXI motif in the B chain(B12–B19 in human) for binding to the relaxin recep-tor [3]. Similar to insulin, a mature two-chain peptide is produced after removal of the C -peptide and ... expressed in the brain and testis. In rodent brain, ana-tomical studies have revealed its predominant expression in neurons of the nucleus incertus of the dorsal pons, and a few other regions of the...
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Báo cáo khoa học: Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation pdf
... gain insights into the structural dynamics of the DNA-bindingdomains of two prototypic strains, human papillomavirus strain 16 and the bovine papillomavirus strain 1. The simulations underline ... toalanine of the residues Lys325 and Lys327, located in the b2–b3 loop, produce a decrease in the DNA bind-ing [22] that is restored upon back mutation intoarginine, indicating the importance of ... (A), the black dotted line represents the S2NMR values; in (A) and (B), the black and the gray point-dashedlines show the values calculated in MD for chain A and chain B,respectively. The...
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Báo cáo khoa học: "Combining a Statistical Language Model with Logistic Regression to Predict the Lexical and Syntactic Difficulty of Texts for FFL" potx
... for the logistic regression model. More informationabout the origin and smoothing of the probabilitiesis given in Section 6.4.2 Measuring the tense difficultyHaving considered the complexity of ... 1),α1 and β1= 0. Thus, when looking for the proba-bility of a text belonging to the baseline level, it iseasy to compute the numerator, since exp(0) = 1. The value of the denominator is the ... p(ti) is the probability of meeting the token ti in French; and n is the number of tokens in a text.2. Deciding what is the best linguistic unit toconsider. The equations introduced above use21tokens,...
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Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf
... bridges in the analogs withrespect to their adenosine moieties.Details of the syntheses will be published elsewhere, and we present, in the Supporting information, only the keysteps leading to the ... lupin enzyme and of 2.1 lm (3) and 2.5 lm (4) for the human counter-part. These Kivalues lie in the range of the Kmvaluesfor Ap4A: 2.5 lm for the narrow-leaved lupin [25] and 2 lm for the ... Comparison of binding and modes of reactivity of dinucleo-tides 3, 4 and 5 by the asymmetrically acting Ap4A hydrolases. (A)Major cleavage of 3 to bc-methyleneoxy-ATP; (B) minor cleavage of 3 to...
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Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
... with the carbonyl oxygen of Met46¢ and the side chain of Lys45¢. Furthermore, P3 is Arg in CA-p2 and Thr in p2-NC. As a result, the carbonyl oxygen of P3 Arginteracted with the amide of Asp29 instead ... clinicalinhibitors in binding to the mutant PRs. The high-resolution crystal structures of PR, PRV82A and PRI84Vcomplexes indicated that the binding affinity formutants was modulated by the ... compare the PR and mutant complexes with the clinical inhibitors. The crystal structures of PR, PRV82A and PRI84VwithUIC-94017, an inhibitor in phase IIB clinical trials, and of PR, PRV82Aand...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... cata-lyzes the dioxygen-dependent oxidative deamination of primary and secondary amines (sarcosine, N-ethylgly-cine, and glycine) and d-amino acids (d-alanine and d-proline), yielding the corresponding ... (PDB:3if9) (blue) structures shows the dif-ferent conformations of the main chain of the a2–a3 loop, seearrows [49]. For the sake of clarity, only the FAD and the ligandbelonging to the wild-type ... size of the side chain, directlyincreasing the volume of the active site, and enhance the flexibility of loops 20 and 130, allowing them toopen wider to accommodate longer ligands. Whenthese...
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Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt
... strainsrevealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was substitutedby thymine and none of the other sites ... acts in the third step of leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, thismutant may be useful in the investigation of unique branched-chain aminoacid ... wild-type BmIVD indicated that all the side chains in the loopconnecting helices I and J are exposed on the surface of the monomer, pointing toward FAD or its neigh-bouring monomer in the tetramer....
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
... substitutions in flanking nucleotides of APBE (lower case). Bold letters in the wild-type sequence indicate the APBE. The first nucleotide of the motif is numbered base one. The individual adenine to guanine ... identifiedfor each APUM in the PFAM analysis. Graycircles represent the localization of repeats in the protein and the numbers indicate the position of each repeat in the PUF domain.Black circles ... RNA-bindingproteins that recognize cis-acting elements usuallylocated in the 3¢ UTR. In recent years, and as a result of great efforts aiming to understand the mechanism of RNA control in animals,...
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