Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... tosubsequent strands of b-sheet (Fig. 1). We have investigated the context-dependent effects of mutations at these sites on Fig. 6. Chevron plot analysis of the logarithm of the r efolding and unfolding ... substitutions imposed on the backbone conformation of WT* shows that the pattern of P37P38P19W45Fig. 1. Ribbon structure modelled on the X-ray structure of human ubiquitin [32]. The position and ... FEBS 2004 Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin Maria D. Crespo, Geoffrey W. Platt, Roger Bofill and Mark S. SearleSchool of Chemistry,...
- 11
- 549
- 0
Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... sbwAFP(red, residues G ly34 to T hr49) and TmAFP (blue, residues Asn29fiGly41). Letters de note the five residues of on e of the threesides of s bwAFP o r s ix residues of on e of two sides of T mAFP. ... so, a considerable number of questions remainbefore we can solve the interaction at the atomic level and understand t he role of the threonine side chains in icebinding. The contradiction between ... tosupport continued growth.ConclusionAnalysis of the structure and examination of the i ce-bindingbehaviour and point mutants of s bwAFP and TmAFPprovides an explanation for their hyperactivity...
- 12
- 716
- 0
Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... depending on the input, interconnections to other information, and an automatic activity decay scheme. In addition, the decay scheme is based on the state of the information, whether it has ... result of acti- vation of a pragmatic representation of a disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension ... other methods, because it enables one to develop a broader perspective of the questions within an analysis of the hypothesis in the con- text of a characterization of the "how" of...
- 5
- 609
- 0
Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... to continue processing the rest of the input data if the workflow is robust (i.e. makesuse of retry and parallelisation) and the error isconfined to a WS (i.e. it does not affect the rest of the ... factory of LRs thatautomates the stages involved in the acquisition,production, updating and maintenance of LRsrequired by Machine Translation (MT), and byother applications based on Language ... Proceedings of the 13th Conference of the European Chapter of the Association for Computational Linguistics, pages 1–5,Avignon, France, April 23 - 27 2012.c2012 Association for Computational LinguisticsLanguage...
- 5
- 532
- 0
Báo cáo khoa học: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression pot
... (Fig. 3C). On the other hand, the SOD2 mutation reporter [SOD2 )1500 ⁄ )1335(T)]showed no effect of either BetA, overexpression of CREB in the presence of BetA, or siCREB alone,further demonstrating ... (2007) DNA bind-ing and phosphorylation induce conformational altera-tions in the kinase-inducible domain of CREB.Implications for the mechanism of transcription func-tion. J Biol Chem 282, ... together, these findings demonstrate thatBetA could achieve an impressive HBV-inhibitoryeffect by specific suppression of SOD2 expression and modulation of the mitochondrial redox balance. The BetA...
- 16
- 352
- 0
Báo cáo khoa học: "Last but Definitely not Least: On the Role of the Last Sentence in Automatic Polarity-Classification" pdf
... polarity-classification, the last proposition of a given text should be of greater importance than the first one (contrary to topic-extraction). Based on preliminary investigations, we sug-gest that the DT of ... session and had an unlimited time to reflect and decide on the polarity of each text. Five seconds after a decision was made (as to whether the reviewer was in favor of the product or not), the ... that location would have been either considerably shorter or longer (de-pending on its distance from the initial location of the mouse curser at the beginning of each trial), and the mouse...
- 5
- 356
- 0
Báo cáo khoa học: Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome ppt
... efficiently than the N-terminal portion of the protein. The Nop53p N-terminal region, on the other hand, is involved in RNA interaction and canpartially complement the conditional strain Dnop53 ... the proteins in the pre-60S complex,but is less concentrated in the nucleolus. These resultsraised the question of whether any of the truncatedmutants of Nop53p, when under control of a constitu-tive ... by PCR reactions with primers for amplification of various regions of the rDNA and snoRNAs. (A) PCR for amplification of 18S and 25S chromatin regions. (B) Amplification of 5.8S region using samples...
- 15
- 380
- 0
Tài liệu Báo cáo khoa học: Hyperactive antifreeze protein in flounder species The sole freeze protectant in American plaice docx
... up 60–65% of the compositions of 5a and 5a-like protein and 55% of ApAFP. Of the otheramino acids, Thr (13%) is the next most abundant, and there are very low amounts of aromatic and long-chain ... concentrations, thermalhysteresis readings were done on dilutions of pureApAFP in 1 mgÆmL)1BSA. The plot of TH as a func-tion of ApAFP concentration with albumin present(Fig. 2B) has the ... (Fig. 1C). The thermal hysteresis activity was entirely concentratedunder the shoulder on the leading edge of the peak(shown by the horizontal bar). Despite the short time-span of the chromatography,...
- 11
- 469
- 0
Báo cáo khoa học: Small exterior hydrophobic cluster contributes to conformational stability and steroid binding in ketosteroid isomerase from Pseudomonas putida biotype B pot
... kH2OUis the unfolding rate constant in the absence of urea and mUà the dependence of the unfolding rate con-stant on urea concentration. The free energy of activationfor the unfolding of KSI-PI ... hydrophobicpacking of the SEHC is important for the conforma-tional stability of KSI-PI. The stability of L125A ⁄V127A was decreased by 0.9 kcalÆmol)1upon the additional mutation of W92A. This additional ... role in the initial recognition of hydro-phobic steroids rather than the binding itself.In conclusion, the mutational studies on the role of the SEHC in KSI-PI demonstrate that the SEHC con-tributes...
- 13
- 305
- 0
Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
... mitochon-drial isolation. The mixtures were pre-incubated for 3 minat 37 °C and then the reactions were initiated by addition of 120 lm NADPH. The incubations were carried out for10 min and then ... between residues 23–33 and that the positively-charged residues at positions 24, 25,26, 28 and 32 are required for mitochondrial targeting. The importance of the positively-charged residues was confirmed ... transfection of aCYP2D6 mitochondrial targeting signal mutant in COS-7 cells. Both the mitochondria and the microsomes from a CYP2D6 stable expression cellline contain the enzyme and both fractions...
- 14
- 407
- 0
Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ