Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx

... al. Pleiotropic leptin receptor signalling FEBS Journal 272 (2005) 109–119 ª 2004 FEBS 119 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines Paul ... suppressor of cyto- kine signalling 3 (SOCS3) [15,23–26]. Binding of SOCS3 to Tyr-985 attenuates leptin signalling by inhi- bition of the recept...

Ngày tải lên: 07/03/2014, 16:20

... relapse and ⁄ or metastasis after complete excision of the cancer, even if they were at stage IA [3]. Despite the progress that has been made in recent decades, the mechanism of lung cancer development, ... subset of human lung cancers To gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele- vance of our findings, we inv...

Ngày tải lên: 07/03/2014, 00:20

... cells and this binding was shown to be independent of 15d-PGJ 2 stimulation. Thereafter, the precise site of action of 15d-PGJ 2 was identified by further 5¢ deletion analysis dissecting the )192 ... (2002) Characteri- zation of the 5¢ untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the T...

Ngày tải lên: 07/03/2014, 21:20

... down-regulated cofactor expression in hTERT-HME cells GR affects gene transcription by a mechanism which is enhanced by cofactors. We therefore characterized the effect of GPR30 on the expression of receptors ... hormone resistance by GPR30. GPR30 most probably a lso induces glucocorticoid resistance by mechanisms other than down-regulation of TIF2 expression. Ligand bindi...

Ngày tải lên: 16/03/2014, 18:20

... higher than that for DABY and PSAO (r ¼ 17) [7]. From this point of view, plant CAOs are more resistant to the inactivation by DAPY than by DABY. Binding of DAPY at the active site of GPAO is dependent ... general base at the active site [3]. This step is followed by hydrolytic release of the aldehyde product and the reduced cofactor is finally reoxidized by mol...

Ngày tải lên: 19/02/2014, 16:20

... entities on the test set, and of these are correct then the precision of a method is . Similarly, if is the number of entities in the human annotated version of the test set, then the recall is . P ... examples is . The run- ning time of the algorithm in figure 1(b) is . This follows because throughout the algorithm the number of non-zero dual paramete...

Ngày tải lên: 23/03/2014, 20:20

... or the inter- action of the calcitonin -receptor- like receptor and the receptor- activity modifying proteins to dictate the ligand specificity of the receptor [14]. Another possibility is that the ... affinity of the receptors in the ER may be the result of several mechanisms: (a) the cholesterol content of the ER membrane is different from that of t...

Ngày tải lên: 23/03/2014, 04:21

... Cohen’s discovery of the ‘tooth-lid factor’ led to the identifica- tion of the genetic causes of certain types of human cancers, and to the genetic classification of a variety of tumors of apparently the ... led to the discovery that EGFR is a tyrosine kinase acti- vated by binding EGF [1]. In 1984, the cDNA of human EGFR was isolated and characterized. A high...

Ngày tải lên: 16/02/2014, 09:20

... opening a new vista for genotype-directed therapy in this disease. KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell ... reposition- ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-T...

Ngày tải lên: 16/02/2014, 09:20

... surface of the cell that pro- duced them. The ECM can be found in different forms, from the hard compositions of bone to the soft structures of connective tissue. Collagens are the main components of ... level of S100A4 showed a greater reduction in the synthesis of TIMP- 1 than did those with a low level of S100A4. Taken together, this study shows that synthesis and...

Ngày tải lên: 18/02/2014, 11:20