Báo cáo khoa học: Factors affecting habituation of PC12 cells to ATP potx
Báo cáo khoa học: Factors affecting habituation of PC12 cells to ATP potx
... ATP leads to habituation of thesecretory r esponse. In this paper, we use amperometricdetection to monitor the habituation of PC12 cells to mul-tiple s timulations of ATP or its agonist. Cells ... beennormalized to the response of PC12 cells to 300 lM ATP under control conditions. The scaled response of PC12 cells to ATP and 2MeSATP in the various conditions studiedareshowninFig.2. Habituation of ... response of a cell to repetitively applied stimulations. Cheever and Koshland[8,10] correlated habituation of the exocytotic response of PC12 cells to ATP with a decrease in Ca2+influx duringATP...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... represented by n variables (within-subjects factors) . Categorical factors are used to divide study popula-tion into subgroups (between-subjects factors) and continuous variables are used as ... CYP3A5 prior to transplantation im-proves the individualization of immunosuppressive therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine ... for the characteris-tics of each individual and several environmental Int. J. Med. Sci. 2010, 7 http://www.medsci.org 95 factors, the role of biological factors affecting the drug absorption,...
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Báo cáo khoa học: C Isotopologue editing of FMN bound to phototropin domains potx
... mg of [2-13C1]- or [3-13C1]glucose,3.5 mg of phosphoenol pyruvate, 0.5 mg of ATP, 6 mg of 2-oxoglutaric acid, 0.6 mg of NAD+, 2.5 mg of NH4Cl,5mgofa13C-isotopologue mixture of ... transfor-mation of these isotopologue libraries into randomlibraries of 13C isotopologues of FMN and their utili-zation for NMR studies of the plant blue light recep-tor, phototropin [5,6].Keywordsblue ... receptor dimerization [16,17].The present study was initiated in order to monitormore closely the light-induced chemical shift modula-tion of the FMN cofactors complexed to LOVdomains of different...
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Báo cáo khoa học: The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs pdf
... transiently stored andrerouted to polysomes to be translated [17]. P-bodiesare highly mobile within the cytoplasm, intermittentlyattaching to stress granules [14]. Factors such as thecytoplasmic ... induction of stress gran-ules. To determine the domain(s) responsible forinduction and ⁄ or recruitment of Roquin to stress gran-ules, we took advantage of the observation that ectopicexpression of ... introduced into HEK 293T cells. The ability of each Roquin construct to spontaneouslyinduce stress granules in transfected cells (in theabsence of sodium arsenite) and to be recruited to stress...
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Báo cáo khoa học: Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin pptx
... Unit, Laboratory of Physiology, School of Medicine, University of Ioannina, Greece2 Laboratory of General Biology, School of Medicine, University of Ioannina, Greece3 Laboratory of Cellular ... induced apoptosis of humantumor epithelial cells [21]. Accumulation of nCLUcorrelated with inhibition of cell proliferation andinduction of apoptosis of human tumor epithelial cells caused ... pools of Bcl-2 [72] and CLU [73–76] may have on the activity of transcription factors such as NF-jB, which mainlyacts as an inhibitor of apoptosis but can also act asa proapoptotic factor [77].Collectively,...
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Báo cáo khoa học: Neutral N-glycans of the gastropod Arion lusitanicus potx
... fractionation or reverse-phasechromatography were analysed by MALDI-TOF andsubjected to exo- or endoglycosidase digestions.MALDI-TOF MS analysisMALDI-TOF MS was carried out as described previously[24]. ... Some of them are commerciallyavailable and widely used as tools in glycomic research. Themajority of these enzymes seem to be part of the degrada-tion and recycling processes of the cells ... of any monosaccharidewas detected. Thus, gastropods seem to be capable of producing many types of structures ranging from thosetypical in human to structures similar to those found innematodes,...
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Báo cáo khoa học: A comparative study of methylglyoxal metabolism in trypanosomatids potx
... vivo assessment of toxicityand pharmacokinetics of methylglyoxal – augmentation of the curative effect of methylglyoxal on cancer-bear-ing mice by ascorbic acid and creatine. Toxicol ApplPharmacol ... d-lactate. Restoration of a functional glyoxalase system byexpression of T. cruzi GLO1 in T. brucei resulted in increased resistance to methylglyoxal and increased conversion of methylglyoxal to d-lactate, ... antiproliferative effects of exoge-nous dihydroxyacetone [22] or endogenous modulation of triose phosphate isomerase in T. brucei [23] couldbe due to methylglyoxal toxicity. Should the absence of GLO1 from...
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Báo cáo khoa học: Alternative binding modes of an inhibitor to two different kinases doc
... useful to be able to predict the likelyinteractions of an inhibitor designed to target one particularkinase with other kinases.It is generally assumed that the mode of binding of aninhibitor to ... shift towards the exit of the cavity, the nonpolar contacts from CK2 to TBB areslightly more numerous (73 contacts) than those of CDK2 to TBB (52 contacts). The closer fit of TBB to the ATP site of ... atoms are magenta).(C) Superposition of TBB bound to pCDK2(carbon atoms, green; bromine atoms, cyan)and TBB bound to CK2 (carbon atoms, darkgreen; bromine atoms, magenta). There is ashiftofabout2.5A˚and...
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Báo cáo khoa học: Revisiting the prediction of protein function at CASP6 potx
... belonging to the class; Exact Pred, number of predictions (out of a total of 14)corresponding to annotations found in UniProt, Entrez Gene andInterPro databases; Exact GOFN, number of predicted GOF ... contacting thepredictors.Each method was assigned to one or more of fivecategories (F1 to F5), here called features, on the basis of the type of information used by predictors. The use of sequence information ... 0.8-1.0F(red)BGOFsGOPsBINDsFig. 2. (A) Fraction of consensus of prediction [F(preds)] as a func-tion of the number of contributing predictions [N(c-preds)]. (B) Frac-tion of consensus of prediction...
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Báo cáo khoa học: On the mechanisms of glycolytic oscillations in yeast potx
... known to be an important effector of the dynamicsin yeast extracts [37].Autocatalytic stoichiometry of ATP The stoichiometry of glycolysis makes the pathwayautocatalytic in ATP, as two moles of ... to theactual drip of the drop. In the case of yeast extracts,we will show below that the slow time-scale corres-ponds to removal of the allosteric phosphofructo-kinase-1 (PFK) inhibitor ATP ... yeast cells, we find that the instability leading to the appearance of oscillations iscaused by the stoichiometry of the ATP- ADP-AMP system and theallosteric regulation of phosphofructokinase,...
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Từ khóa: Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Chuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ