... epigeneticmodifications. The two chromatin states, of gene-active unwrapped euchromatin at the nucleoplasm, and of gene-silenced condensedheterochromatin at the vicinity of the INM are circled. In the latter ... degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involve-ment of the rest of the brain. The question of how mutations in the same gene orgroup of ... For example, the combination of H4 K8 acetylation, H3K14 acetylation, and H3 S10 phosphorylation is oftenassociated with transcriptional activation. Conversely,tri-methylation of H3 K9 and the lack of...