... H, Obata K, Yamada H, Hay-akawa T, Fujikawa K & Okada Y (2000) Matrix metal-loproteinases and < /b> tissue inhibitors of < /b> metalloproteinases in synovial fluids from patients with rheumatoid arthri-tis ... conversion of< /b> b 12dimers to a 1 and < /b> a 2monomers is apparent in thislane, to give an increased level of < /b> both the < /b> a chains and< /b> a slightly increased mobility of < /b> the < /b> a 2chain. This indi-cates the < /b> presence ... demonstrated by cleavage of < /b> denatured sub-strate (denat). The < /b> positions of < /b> the < /b> uncut collagen b and < /b> a chains (b 11, b 12, a 1 and < /b> a 2) are shown. Cleavage of < /b> wild-type and < /b> mutatedtype I collagen...