Báo cáo khoa học: DNA mismatch repair system Classical and fresh roles potx

... compilation ª 2006 FEBS 1619 MINIREVIEW DNA mismatch repair system Classical and fresh roles Sung-Hoon Jun, Tae Gyun Kim and Changill Ban Department of Chemistry and Division of Molecular & Life ... [22]. DNA polymerase III, single-stranded DNA- binding protein and DNA ligase carry out repair synthesis [3]. Eukaryotic mismatch repair All eukaryotic organis...

Ngày tải lên: 07/03/2014, 12:20

... suppressor genes and inactivation of DNA repair systems are a result of both genetic and epigenetic abnormalities. The correlation between the status of -CpG-island hypermethylation and ⁄ or mutations ... the other hand. EGCG can bind to GpC-rich regions of DNA. Radiation can damage the respective genes, thereby inviting repair enzymes [2]. This facilitates repair- based DNA d...

Ngày tải lên: 18/02/2014, 14:20

... homologous pairing and strand exchange during homologous recombination and double-strand break repair [1,2]. Rad51 and Rad52 colocalize in distinct nuclear foci in response to DNA damage [3]. Yeast rad52 ... recombinational repair machinery to a DNA double-strand break in yeast. Mol Cell 12, 221–232. 8 Benson FE, Baumann P & West SC (1998) Synergistic actions of Rad51 andRad...

Ngày tải lên: 16/03/2014, 14:20

Ngày tải lên: 23/03/2014, 03:20

... as gold standard roles and training data. More re- cent learning work has applied bootstrapping ap- proaches (Swier and Stevenson, 2004; He and Gildea, 2006), but these still rely on a hand la- beled ... roles have required a pre-defined set of roles (Grenager and Manning, 2006) and often a hand-labeled seed corpus (Swier and Stevenson, 2004; He and Gildea, 2006). In this p...

Ngày tải lên: 23/03/2014, 16:21

... and HinfI for 3 h and recovered by ethanol precipitation. The precipitated DNA was dissolved in 3 lL of water and added into the ligation mixture [100 ng each of landmark- and HinfI-adapter and ... restric- tion-modification systems, which distinguish self and nonself DNA to protect bacteria from invaders. In this system, the host DNA is methylated and only unmeth- ylated...

Ngày tải lên: 19/02/2014, 02:20

... DNA without any protein; lanes 2, 3 and 4 correspond to DNA complexes with p53(1–363), p73d and p73b, yielding retarded bands R 53 ,R 73d and R 73b , respectively. In lanes 5–7, the protein DNA ... one strand and two AG steps in the other. The mdm2 target, whose interaction with p53 was most strongly affected by DNA cis-platination, contains GG, GGG and AG motifs in one stran...

Ngày tải lên: 19/02/2014, 05:20

... of single-strand DNA (ssDNA) and assimilation of ssDNA into homologous super-coiled duplex DNA. J Biol Chem 276, 41906–41912. 10 Nara T, Hamada F, Namekawa S & Sakaguchi K (2001) Strand exchange ... 2006) doi:10.1111/j.1742-4658.2006.05170.x Rad51 and disrupted meiotic cDNA1 (Dmc1) are the two eukaryotic DNA recombinases that participate in homology search and strand exchange r...

Ngày tải lên: 19/02/2014, 07:20

... repair to Denver replaces the reparandum. Shriberg and Stolcke (1998) studied the location and distribution of repairs in the Switchboard cor- pus (Godfrey and Holliman, 1997), the primary cor- pus ... explicit editing terms (e.g., “I mean”), par- enthetical asides and repairs. Of these, repairs pose particularly difficult problems for parsing and related Natural Language Processin...

Ngày tải lên: 20/02/2014, 04:20

... brows- ing and retrieval system. The prototype is in an early stage of development, and we are currently exploring the role of nat- ural language for interacting in this rela- tively unfamiliar and ... unfamiliar and complex domain. We briefly describe the design and implemen- tation status of the system, and then focus on how this system is used to elicit useful data for suppo...

Ngày tải lên: 20/02/2014, 12:20