Báo cáo khoa học: Therapeutic targeting of molecules involved in leukocyte–endothelial cell interactions potx

... MINIREVIEW Therapeutic targeting of molecules involved in leukocyte–endothelial cell interactions Nicole C. Kaneider 1 , Andrew J. Leger 1,2 and ... (GPCR) signaling [6]. Several anti- in ammatory drugs indirectly inhibit components involved in leukocyte–endothelial cell interactions. For example, compounds that block interleukin (IL)-1 or ... cell extracellular...

Ngày tải lên: 07/03/2014, 12:20

... compounds (Fig. 6). In this way, amino acid res- idues of different segments of NADP-ME2 swapped in the construction of the chimeras are involved in the fumarate activation of the pyruvate reductive ... effectors. In this work, the regions involved in some of these differential regulations were mapped in the primary structure of each isoenzyme. Succinate, fumarate,...

Ngày tải lên: 23/03/2014, 04:20

... shown). Role of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of ... suggesting the importance of PKA in protein trafficking [47,48]. In this study, we used PKA knockout mutants to determine the role of PKA in mitochondrial tar...

Ngày tải lên: 18/02/2014, 16:20

... marked increase in nuclease resistance in vitro [54]. Similar targeting of PNAs to mitochondria also failed to show inhibition of mtDNA replication in intact cells [21,23], suggesting that access of ... useful in investi- gating the rate of turnover of mtDNA and in the derivation of mtDNA-free (q°) clones of the large number of cell lines where the classical trea...

Ngày tải lên: 20/02/2014, 11:20

... sensitivity of preHoloHiPIP targeting with that of the targeting of the Fig. 5. Requirements for membrane targeting of HiPIP. (A) 55 Fe tracing data obtained using standard targeting assays (see ... folded. During membrane targeting, the protein retained its cofactor, indicating that it was targeted in a folded state. Membrane targeting did not require a twin arginine mot...

Ngày tải lên: 23/03/2014, 21:20

... post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiation and stained with hematoxylin and eosin. One of two independent experiments ... important class of post-transcriptional regulators of metabolism in several cell types, including b-cells, muscle cells, and adipocytes [1]. They appear to be involved...

Ngày tải lên: 18/02/2014, 08:20

... extension to the protein kinase folds back on the kinase domain and interferes with the substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts ... hexadecameric enzyme consisting of four copies of four subunits: (abcd) 4 . An intrinsic calmodulin (CaM, the d subunit) binds directly to the c protein kinase chain. The interaction site o...

Ngày tải lên: 19/02/2014, 17:20

... that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA. Transport of GABA by GAT1 across the cell mem- brane ... protein stability and disturbed intracellu- lar trafficking. N-Linked oligosaccharides, in particular their terminal structures, are involved in the regulation of...

Ngày tải lên: 19/02/2014, 17:20

... Linguistics Improving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural...

Ngày tải lên: 20/02/2014, 05:20

... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1

Ngày tải lên: 20/02/2014, 07:20