Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
... 20 06 FEBS 3791 Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells Shaoping Zhang 1 , Hong Liu 1 , Junxi Liu 1 , ... p38 mitogen activating protein (MAP) kinase (p38 kinase) followed by caspase-3 acti- vation [24 ]. Mitogen-activated protein kinases (MAPKs...
Ngày tải lên: 07/03/2014, 12:20
Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt
... Biol Chem 27 6, 24 17 24 26. 18 Sine SM (20 02) The nicotinic receptor ligand binding domain. J Neurobiol 53, 431–446. 19 Sine SM, Wang HL & Bren N (20 02) Lysine scanning mutagenesis delineates ... structural model of the nicotinic receptor ligand binding domain. J Biol Chem 27 7, 29 210 29 223 . 20 Miyazawa A, Fujiyoshi Y & Unwin N (20 03) Structure and gating mechanism of...
Ngày tải lên: 19/02/2014, 07:20
Báo cáo khoa học: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals doc
... Sade ´ eW (1994) Activation of a GTP-binding protein and a GTP- binding-protein-coupled receptor kinase (beta-adrener- gic-receptor kinase- 1) by a muscarinic receptor m 2 mutant lacking phosphorylation ... [ 35 S]GTPcS binding by carbamylcholine in the presence of 10 )6 M GDP. M 2 (N-D)I3del alone caused no increase in [ 35 S]GTPcS binding [25 ]. (B) Decrease in GDP af...
Ngày tải lên: 07/03/2014, 11:20
Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... of KLF2 increased diet -induced Fig. 3. DNA binding activity and transcription activity of KLF4 to the KLF binding element of hSR-BI promoter in PMA-differentiated THP-1 macrophages. (A) Binding ... 27 7 (20 10) 3780–3788 ª 20 10 The Authors Journal compilation ª 20 10 FEBS tion of China (30900 623 ), and the Doctoral Fund of Ministry of Education of China (Fund for New...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Dimers of light-harvesting complex 2 from Rhodobacter sphaeroides characterized in reconstituted 2D crystals with atomic force microscopy docx
... observed tilt of LH2’s within the square lattice was not due to an intrinsic property of LH2’s of Rhodop. acidophila, but was caused by specific interactions induced by packing. In contrast, tilted LH2’s ... protruding LH2 rings, approximately 120 ° (Fig. 2A) and 90° (Fig. 2B), indicated two types of zig-zag lattice. The inset of Fig. 2A shows a high-magnification image of L...
Ngày tải lên: 18/02/2014, 18:20
Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt
... sequence includes part of the Pro20–Xaa21–Thr 22 Pro23–Arg24 sequence, which is essential for phosphorylation of Thr 22 by cyclin- dependent protein kinase 5 [41–45]. It is not known now whether Thr 22 ... [ 3 H]cGMP binding was initiated by adding indicated concentrations of [ 3 H]cGMP (C-1). The [ 3 H]cGMP binding in C-1 is ana- lyzed by Scatchard plotting (C -2) . Roles...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... [ 126 , 127 ]. Activated p21-activated kinase 1 and ROCK1 phosphorylate and activate LIM-kinases 1 and 2, respectively [ 128 –1 32] . Eventually, LIM-kinases 1 and 2 phosphorylate actin-depolymerizing ... & Sugino H (20 02) Regulation of endocytosis of activin type II receptors by a novel PDZ TGFb signaling and small GTPases D. Kardassis et al. 29 62 FEBS Journal 27 6 (20 09...
Ngày tải lên: 07/03/2014, 01:20
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... protein kinase C pathway, or the cAMP- dependent protein kinase A pathway [28 ]. Here, cAMP may modulate AP -2 activity by protein kinase A -induced phosphorylation of the transcription factor [29 ]. So ... cells Sox9 Sox9 Sox5 Sox6 AP -2 α Runx2 Runx3 Runx2 Runx2 Fig. 2. Functional role of AP-2a and AP-2e in chondrogenesis. Overview of the differen- tiation stages du...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... Journal 27 7 (20 10) 24 63 24 73 ª 20 10 The Authors Journal compilation ª 20 10 FEBS 24 63 of the conserved TXY motif in the activation loop of MAPKs, resultin g in MAPK activation. Activated MAP- Ks ... & Keyse SM (20 07) Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26 , 320 3– 321 3, doi: 121 04 12 [pii]...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... residues 1 21 9), S -22 88 (2. 2-fold) and FX (4.3-fold) were still processed at a reduced rate by G372A-FVIIa, and K m for S -22 88 was increased by a factor of four (Fig. 1A). Results obtained with S -23 66 ... chain of Trp364 (21 5) moves closer to the S2 pocket, leading to rearrange- ment of residues 364–369 (21 5 22 1A), as seen for a structure of FVIIa obtained in the pr...
Ngày tải lên: 18/02/2014, 08:20