Báo cáo khoa học: The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin pot

... compilation ª 2006 FEBS The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin C. James Hastie 1, *, ... type S. cerevisiae Drosophila Human Catalytic subunit Pph3p Ppp4c ⁄ Pp4 ⁄ cmm Ppp4c ⁄ PP4 ⁄ PPX Core regulatory subunit of Pph3 ⁄ Ppp4c...

Ngày tải lên: 07/03/2014, 12:20

... 2006) doi:10.1111/j.1 742 -46 58.2006.0 543 0.x The vertex of the adenoviral capsid is formed by the penton, a complex of two proteins, the pentameric penton base and the trimeric fiber protein. The penton contains ... of the viral cap- sid, the penton base also contains an Arg-Gly-Asp (RGD) motif that acts as a trigger for endocytosis of the adenovirus into the ho...

Ngày tải lên: 19/02/2014, 06:20

... How to measure and predict the molar absorp- tion coefficient of a protein. Protein Sci 4, 241 1– 242 3. 48 Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage ... affected by the level of sulfur (supplementary Fig. S4), suggest- ing that the levels of these mRNAs are not regulated in a manner responsive to the exp...

Ngày tải lên: 07/03/2014, 05:20

... [ 14] . These unique lipid modifications greatly reduce the diffusibility of Shh-Np and tether it to the cellular membrane. However, they are necessary to regulate the movement of the protein to ... 5E,F). These obser- vations imply that these two proteins interact with overlapped targets. As the intensity of the fluorescence of these proteins was almost the same,...

Ngày tải lên: 18/02/2014, 16:20

... compounds of substrates, products and regulators of other enzymes in the human nucleotide metabolism (Table S1). The library can then be seen to constitute the specific metabolome of the nucleotide metabolism, ... respec- tively. b R free is the R factor for the test set (5% of the data). c According to MOLPROBITY [35]. M. Welin et al. Studies of the human PRT...

Ngày tải lên: 15/02/2014, 01:20

... accession numbers of the T-bet genes are as follows: human, CH471109; zebrafish, FN435332. The EMBL accession numbers of the STAT6 genes are as follows: human, AF417 842 ; zebrafish, FN4353 34. The EMBL accession ... relationship between the expression of these transcription factors and the cytokine genes known to be produced by dif- ferent T-cell subtypes in mammals. Thes...

Ngày tải lên: 16/02/2014, 09:20

... adipocytes, the translo- cation of Bax from the cytoplasm into the mitochon- dria, cytochrome c release and cleavage of caspase-3 were all observed (Fig. 4B–D). To confirm the involvement of Bcl-2 ... Bad causes the release of Bax, which is translocated into the mitochondria, where it activates the mitochondrial pathway (Fig. 4A,B). Thus, the intrinsic apoptotic pathw...

Ngày tải lên: 16/02/2014, 09:20

... In addition to actin, other host cell proteins have been shown to bind to the virulence factor YpkA, including OTUB1 [13]. In order to investigate the role of OTUB1 in Yersinia invasion of HEK293T ... kDa 7 64. 39 y6 617. 34 y5 338.16 b4 290.17 y2 175.13 y1 211.16 b2 41 8.23 y3 45 1.25 b5 546 .31 y4 678.35 y11++ 877 .49 y7 1192.62 y10 1077.60 y9 985.52 y17++ 1355.69 y11...

Ngày tải lên: 16/02/2014, 15:20

... (P1 640 3) H1.3 (P1 640 2) H1 .4 (P1 041 2) H1.5 (P1 640 1) pS36 [42 ,43 ], pT 146 [42 ,43 ] pS37 [42 ,43 ], pT 147 [42 ,43 ] pT18 [42 ,43 ,47 ], pS172 [41 ,42 ,47 ] pS18 [41 ,43 ], pT138 [41 43 ] pS173 [41 43 ] pS189 [41 43 ] ... linker histone variants Location and structure of the linker histones Historically, the location of the globular domain of the linker histone has bee...

Ngày tải lên: 18/02/2014, 08:20

... in NOS, the second electron is provided to the heme- dioxy species by a bound H 4 B cofactor rather than by the flavoprotein domain [16]. The H 4 B radical is then reduced within the enzyme by the ... on NOSoxy or the need for the flavoprotein to sense when an electron is required by the heme versus the H 4 B radical at discreet steps in the reaction cycle (Fig....

Ngày tải lên: 18/02/2014, 11:20