Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf

... FEBS REVIEW ARTICLE Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration Xu Hou, Marie-Isabel Aguilar and David H. Small Department ... six b-strands instead of eight, with the C and D strands and the intervening loop forming a large loop, expos- ing some hydrophobic residues...

Ngày tải lên: 07/03/2014, 10:20

... their binding to and activa- tion of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6–Axl system is the unique ability of Gas6 and pro- tein S to tether their ... itself against and interact with the membrane, thus enabling the SHBG domain to bind to the receptor on either the same or another cell. Axl, Sky and Mer in cancer...

Ngày tải lên: 19/02/2014, 05:20

... we linearize the system of Eqn (3) in the vicinity of the steady state. We do this to investigate the stability of this state. In this way we obtain the in uence a small change in the concentration of ... cycles in such a combination do not touch each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The...

Ngày tải lên: 19/02/2014, 16:20

... two N-terminal serines within the IjBs, lead- ing to their ubiquitination and degradation through the proteasome pathway. The alternative pathway involves the processing and cleavage of the p100 precursor ... activated in neurons and is neurotoxic when induced in glial cells [60]. Recent progress in understanding the NF-jB dichotomy shows that within the same...

Ngày tải lên: 07/03/2014, 03:20

... acid, arginine catabolism to NO and polyamines NG, aorta endothelial cells Low affinity transporter and arginase share the control of the fluxes through the pathways involving arginine as a precurser of nitric oxide and polyamines ODE ... computational modeling. Here, computational modeling does not refer to statistical models or models of data mining but rather to a mathemati...

Ngày tải lên: 14/02/2014, 14:20

... passed. The challenge presented here, then, is to gain a bet- ter understanding of the significance of the different degrees of chromatin condensation and chromatin modification that prevail in the ... varia- tion and complexity in the number of nucleosomes dis- rupted, the histone composition of the remaining nucleosomes, and the number and nature of p...

Ngày tải lên: 14/02/2014, 18:20

... repressing the indicated targets and presumably hundreds of other as yet unidentified targets. (B) miR-34a and the miR-34a-binding site in the 3¢ UTR of genes shown in (A). miRNAs and cell signaling ... fac- tor induced the expression of miR-221 and miR-222 in PC12 cells, and that this induction is dependent on sustained activation of the ERK1 ⁄ 2 pathway [20]...

Ngày tải lên: 14/02/2014, 19:20

... (RISC)-loading complex (RLC) in an ATP-dependent manner [20]. Next, one strand (the passenger strand) of the miRNA is removed from the RLC, whereas the other strand (the guide strand) remains in the ... numbers in the ‘binding sites’ column represent the distance (bp) between the stop codon and binding sites of seed sequences in the miRNAs. The letters ‘c’ a...

Ngày tải lên: 14/02/2014, 19:20

... novel insight into the molecular understanding of cardiac excitability. However, considering the inherent capacity of miR- NAs to target a broad range of proteins, the link between miR-1 and arrhythmia ... proteins involved in fibrosis, including multiple collagens, fibrillins and elastin [75]. miR-29 is dramatically repressed in the border zone flanking the infracted...

Ngày tải lên: 14/02/2014, 19:20

... [46]. The similarity in the K m values is attributable to the uracil moiety binding in the same fashion [38], which could trigger the initial binding of both substrates. In UpG, the binding of the guanine ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonucleases. J Mol Biol 45, 491–511. 33 Ui N (1971) Isoelectric points a...

Ngày tải lên: 14/02/2014, 22:20