Báo cáo khoa học: Structure of coenzyme F420H2 oxidase (FprA), a di-iron ﬂavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O ppt

... biochemical data that indicate one iron to bemore loosely bound to the enzyme than the other [34]. The low occupancy of the proximal iron leads to anincrease of the temperature factor of its ... O2oxidoreductase from Desulfovibrio gigas, rubredoxin:NO ⁄ O2oxidoreductase from Moorella thermoacetica,F420H2 oxidase from Methanobrevibacter arboriphilus,and other FprAs from methanogenic archaea assumed to ... His151 dramaticallychange their conformation; in particular, the last of these movesmore than 10 A ˚as part of the switch loop (tetragonal crystalresolved to 2.25 A ˚). (C) In the active oxidized...

Báo cáo khoa học: Structure–cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants ppt

... new software packagefor the handling and analysis of thermal denaturationdata of biological macromolecules. J Thermal Anal 38,2779–2790.29 Marky LA & Breslauer KJ (1987) Calculating thermo-dynamic ... M, Piccialli G, Di Donato A, Parente A & D’Alessio G (1992) The dual-modequaternary structure of seminal RNase. Proc Natl AcadSci USA 89 , 1870–1874.2 Mazzarella L, Capasso S, Demasi D, ... opposite to Arg80 (Fig. 8). The observation of models built with the X-ray structure of the reduced dimer of BS-RNase (PDBcode 1TQ9) as template indicate that all of the variantsmaintain a quaternary...

Báo cáo khoa học: "TENSE GENERATION IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING: SOME ISSUES IN THE DESIGN OF THE VERB EXPERT" pot

... for example, has no declensions, it makes minimum use of the subjunctive mood and adopts 'natural' gender instead of the grammatical one. The language, on the other hand, has become ... verbs. The system, organized around the classical architecture of an ITS (Sleeman and Brown 1982), consists essentially of: - the Tutor, which is devoted to manage the teaching activity and the ... referenced in the same sentence. Other information can be derived from the mood and aspect of the verb, from the lexical category which the verb is a member of and, more generally, from several kinds...

Báo cáo khoa học: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus docx

... 6-Oposition of the uronic acid and at the 3-O and 6-Oposition of the amino sugar. The amino group of the glucosamine may be either acetylated or sulfated. The two major families of cell surface HSPGs are ... tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carci-noma). Prior to entry into basal cells, virions attach to heparan sulfatemoieties of the basement membrane. This ... withits attachment receptor heparan sulfate in combinationwith a mutational approach will provide a solution to these apparent discrepancies.In recent years, it has become clear that a secondarynon-HSPG...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... of an HDAC to reform a repressed state. The principal role of H3-K36 methyl-ation in mammalian cells remains far from clear. Thismodiﬁcation can recruit the HATs MOF and HBO1,and both factors ... [85]. Mast cells express GATA-2 as well asNFAT and AP-1, and GATA-2 initiates the formation of an additional discrete GATA-2 ⁄ AP-1 enhanceo-some-like complex existing upstream of the two NFA-T ... NFAT and AP-1 have the potential to recruit the HATs CBP and p300 whichmay allow the formation of stable enhanceosomes.AP-1, and potentially NFAT, are also able to recruitSWI ⁄ SNF family...

Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

... was to better understand the catalytic mechanism of RNase Sa2 and to accountfor the differences in catalytic activity between RNasesSa2 and Sa. On the basis of the crystal structures of RNase ... intermediate. We also propose that the seven-fold higher efﬁciency of RNA cleavage by RNaseSa than by RNase Sa2 can be at least partly explainedby the Val43 (RNase Sa) to Arg45 (RNase Sa2)substitution. ... GP, Struminskaya NK, Bor-zykh OA, Kipenskaya LV, Znamenskaya LV, LEschins-kaya IB, Chernokalskaya EB & Hartley B (1994)Mutational analysis of the active site of RNase of Bacil-lus intermedius...

Tài liệu Báo cáo khoa học: Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR docx

... TetrasialylPA glycan Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6(Neu5-Aca2-3Galb1-3(Neu5Aca2-6)GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Ma na1-3)Manb1-4GlcNAcb1-4GlcNA-PAwas used as a control sugar to ... PA-oligosaccharides,GalNAca1-3(Fuca1-2)Galb1-3(Fuca1-4)GlcNAcb1-3Galb1-4Glc-PA and Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6(Neu5Aca2-3Galb1-3(Neu5Aca2-6)GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-3)Manb1-4GlcNAcb1-4Glc-NAc-PA ... spectra of SAIL and ULAt3g16450.1Although the concentration of the SAIL protein waslower than that of the UL protein by a factor of three(SAIL, 0.2 mm; UL, 0.6 mm), the NMR spectra of SAIL At3g16450.1...

Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

... on their evolutionary relationship and tertiary structure. Plant APs have been distributed among families A1 , A3 , A1 1 and A1 2 of clan AA, and family A2 2 of clanAD. The majority of plant APs ... Molecular and biochemical characterisation of two asparticproteinases TcAP1 and TcAP2 from Theobroma cacao seeds.Planta 215, 754–762.12. Park, H., Yamanaka, N., Mikkonen, A. , Kusakabe, I. &Kobayashi, ... this intracellular location are the secreted APs found in the extracellular matrix of tobacco[64] and tomato leaves [63], cardosin B found in the extracellular matrix of the ﬂoral transmitting...

Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt

... by adding a lipidic group (2-amino-D,L-dodecanoic acid, Laa) to either the N-terminus (LaaMII) or to Asn5 (5LaaMII). The N-terminal LaaMII was shown to have a tertiary structure similar to ... assay,dACh-evoked currents in parasympatheticneurons from rat intracardiac ganglia.Fig. 2. Surface representations of ImI andPnIA. (A) The three-dimensional structure of ImI. The heavy atoms ... University of Queensland, Brisbane, QLD, Australia a- Conotoxins that target the neuronal nicotinic acetylcho-line receptor have a range of potential therapeutic applica-tions and are valuable probes...

Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf

... revent the FP from immersing too d eeply into the apolar core of the membrane. Our data are alsocompatible with the observation that truncation of t hemembrane-spanning region of HA2 to the extent ... Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China The structure and membrane interaction of the internalfusion peptide (IFP) fragment of the avian sarcoma andleucosis virus (ASLV) envelope ... wererecorded from 260 to 190 nm at a scanning rate of 50 nm Æmin)1with a time constant of 2 s, step resolution of 0.1 nm, and bandwidth of 1 nm. The ﬁnal spectra weretaken from the average of ﬁve s cans....

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