Báo cáo khoa học: Folding and turnover of human iron regulatory protein 1 depend on its subcellular localization pdf
Báo cáo khoa học: Folding and turnover of human iron regulatory protein 1 depend on its subcellular localization pdf
... mitochondria A. Martelli et al. 10 92 FEBS Journal 274 (2007) 10 83 10 92 ª 2007 The Authors Journal compilation ª 2007 FEBS Folding and turnover of human iron regulatory protein 1 depend on its subcellular ... IRP1 strongly depends on its cellular environment, in contrast to other members of the aconitase family. Abbreviations hAco2, human mitochondrial ac...
Ngày tải lên: 07/03/2014, 10:20
Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram potx
... Effects of reducing agents on DS-dependent inhibition of NAT1. Conditions % of control activity a NAT1 + DS 0.5 ± 0.7 NAT1 + DS + GSH (1 m M) 1. 2 ± 0.9 NAT1 + DS + GSH (2 m M) 1. 3 ± 0.6 NAT1 + DS ... reaction. The second-order rate constant for the inhibition of NAT1 by DS (k i ) was deduced from the slope of k obs as a function of the DS concentration [DS], and was 6 ·...
Ngày tải lên: 07/03/2014, 02:20
Báo cáo khoa học: Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition potx
... least-square fit of Eqn (1) to the data of Fig. 1 yields the constants given in the legend of Fig. 1. The values of k cat ⁄ K m and k cat for catalysis by C140S– Table 1. Mutations present in 11 confirmed ... number of units of both Taq and Pfu DNA polymerases were used for the amplification of the reassembled product. Preparation of enzymes The expression vectors contai...
Ngày tải lên: 07/03/2014, 11:20
Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... & Sugai S (19 89) The evolution of lysozyme and alpha-lactalbumin. Eur J Biochem 18 2, 11 1 11 8. 13 Qasba PK & Kumar S (19 97) Molecular divergence of lysozymes and alpha-lactalbumin. Crit Rev ... Dobson CM (19 97) Structural characterisation and comparison of the native and A-states of equine lysozyme. J Mol Biol 268, 903–9 21. 19 Morozova-Roche LA, Jones JA, Nop...
Ngày tải lên: 29/03/2014, 21:20
Tài liệu Báo cáo khoa học: Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD) K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein pptx
... 3.69 24.4 · 10 3 19 Confidence limits (68%) 3.23–4.03 23.8–24.9 · 10 3 Wilkinson 3.68 24.6 · 10 3 19 .1 Standard error 0.305 6 21 K364R Direct linear 5.38 25.5 · 10 3 19 .8 Confidence limits (68%) 5.09–5.87 ... Pittsburgh, PA 15 2 61, USA (Received 13 January 2005, revised 24 June 2005, accepted 25 July 2005) doi :10 .11 11/ j .17 42-4658.2005.04878.x Two novel rare mutations, M...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... December 2 010 , revised 10 February 2 011 , accepted 5 April 2 011 ) doi :10 .11 11/ j .17 42-4658.2 011 .0 812 8.x Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription ... ini- tiation of transcription elongation [13 7]. The initiation and elongating phases of the tran- scription cycle are characterized by distinct sets of h...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... 606-85 01, Japan Fax: + 81 75 753 4544 Tel: + 81 75 753 4523 E-mail: gtsuji@pharm.kyoto-u.ac.jp (Received 10 November 2 010 , revised 6 February 2 011 , accepted 1 March 2 011 ) doi :10 .11 11/ j .17 42-4658.2 011 .08087.x MicroRNAs ... miRNAs and cell signaling FEBS Journal 278 (2 011 ) 16 10 16 18 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 16 13 miRNAs act as feedback reg...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt
... chenxifw@yahoo.com.cn; xiangfeng_cong@yahoo.com.cn (Received 26 April 2 010 , revised 27 June 2 010 , accepted 10 July 2 010 ) doi :10 .11 11/ j .17 42-4658.2 010 .07770.x To understand the potential paracrine roles of interleukin-1b (IL-1b), tumour ... effects, decreasing protein production and gene expression for IL-1b and TNF-a [11 ]. To address these paradoxes of both pro- and...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... cross-rotation and translation functions in the 10 –4 A ˚ resolution range. The solution of the rotation function was used to perform the translation function calculations in both the P3 2 21 and P3 1 21 ... replacement and refined at a resolution of 2.0 A ˚ . The monomer present in the asymmetric unit contains 332 residues out of 336, one zinc ion, one DHAP molecule, one gly...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... calculated energy 13 10 28 14 24 25 12 11 17 Calculated energy 11 10 14 18 8 8 23 0 11 Similar amino acids 8 7 6 9 4 3 6 8 7 Size change 12 15 )1 )59)3 516 Hydrophobicity difference )7 )10 27 03 074 Surrounding ... p53R2 97 0 1 M246V p53R2 56 0 1 C275S p53R2 223 0 1 Q192R WAF1 32 67 13 5 D208E WAF1 ⁄ MDM2 2 12 36–96 T256A WAF1 11 40–86 N263D WAF1 ⁄ MDM2 1 18 54 10 8 V272...
Ngày tải lên: 18/02/2014, 11:20