Báo cáo khoa học: Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10–23 potx

... modification on the catalytic activity of deoxyribozyme 10–23 The functional role of the individual phosphate groups in the catalytic core of deoxyribozyme 10–23 was examined by determination of the thio ... deoxyribozyme 10–23 In order to obtain a deeper insight into the functional role of the oxygen atoms of the P5 phosphate group...

Ngày tải lên: 07/03/2014, 10:20

... receptor–ligand interactions of the histamine receptors. Elucidation of the structure and dynamics of membrane proteins is a challen- ging task essential for proper understanding of the func- tioning of fundamental ... [28]. The N-terminal sequence of the H1 receptor indeed contains two N-linked glycosylation consensus sites, but in prelim- inary studies no binding to...

Ngày tải lên: 30/03/2014, 14:20

... production of inter- leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The antibacte- rial defence of the intestinal mucosa depends in part on stimulation of CCK ... euge- nin, indicating that eugenin is indeed acting through CCK 2 receptors. To further investigate the interaction of eugenin with CCK 2 receptors, we investigated...

Ngày tải lên: 19/02/2014, 16:20

... terminal in the grammar. If A is a terminal then G A is the distribution that puts all of its mass on the unit tree (i.e., tree consisting of a single node) labeled A. If A is a nonterminal then G A is ... parse of that string with a PCFG approximation to the adaptor grammar. This PCFG contains a production for each adapted subtree in the parses of the other strings i...

Ngày tải lên: 20/02/2014, 09:20

... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocar- din, and that the RPEL motif itself is an actin-binding element. RPEL1 and RPEL2 of myocardin bind actin weakly ... as STARS-interacting proteins. These novel proteins con- tain four LIM domains and a C-terminal villin head- piece domain, which mediates actin-binding in several proteins, suc...

Ngày tải lên: 07/03/2014, 01:20

... written in the form of appropriate tables of rules. The paper raises the question of the increasing complexity of the tables when more than the most elementary natural-language con- ditions are included, ... machine translation. It must be noted at the outset that in this author’s opinion the aim of the automatic-parsing component of a machine-translation...

Ngày tải lên: 07/03/2014, 18:20

... confirm the expression of prosemin mRNA in some cell lines. A band of the predicted size (500 bp) of the PCR product was observed for most of the cell lines tested, including HPC-YO and HPC-YS, in ... 31 000, indicating successful digestion of the artificial trypsinogen pro-enzyme frag- ment. The amount of 31 kDa prosemin increased in pro- portion to the time of...

Ngày tải lên: 16/03/2014, 23:20

... critical role in the proliferation of MH7A cells. In order to determine whether MLN51 is involved in the anti-apoptosis as well as cell proliferation of MH7A in response to GM-CSF, we examined the apoptosis ... angiogenesis in arthritic joints [2–4]. Several cytokines and RA factors existing in the RA environment stimulate the overgrowth of FLSs, leading to the a...

Ngày tải lên: 23/03/2014, 07:20

... dopamine- selective transporter is found. Keywords: insect; neurotransmitter; transporter; dopamine; octopamine; cocaine. The catecholamine dopamine (DA), the phenolamine octopamine (OA) and the indolamine ... does the moth OAT substitute for DAT in dopami- nergic signaling pathways in the moth CNS, and what is the nature of the mechanism that substitutes for OAT in the...

Ngày tải lên: 23/03/2014, 20:22

... (muscle). The application of the ANOVA technique allowed us to segregate the main (intrinsic) activities of the respective elements from the effects of their interactions. Using this approach, the upstream ... sequences present in the respective constructs are shown in the left portion of the figure as solid black lines. The upper line shows the linkage of...

Ngày tải lên: 23/03/2014, 20:22