Báo cáo khoa học: Meiosis and small ubiquitin-related modifier (SUMO)conjugating enzyme, Ubc9 potx

... ARTICLE Meiosis and small ubiquitin-related modifier (SUMO)- conjugating enzyme, Ubc9 Kengo Sakaguchi, Akiyo Koshiyama and Kazuki Iwabata Department of Applied Biological Science, Faculty of Science and ... with CcUbc9, CcTopII and CcPCNA. Moreover, both TopII and PCNA homologs were known as Ubc9 interactors and the targets of sumoylation. Immunocytochemistry demonstr...

Ngày tải lên: 07/03/2014, 09:20

... Inter- national Conference on Acoustics, Speech and Signal Processing, pages 181–184. [Kurland and Lee2004] O. Kurland and L. Lee. 2004. Corpus structure, language models, and ad-hoc infor- mation retrieval. ... discounting (Witten and Bell, 1991), Jelinek-Mercer interpolation (Jelinek and Mercer, 1980), and Kneser-Ney (Kneser and Ney, 1995). In the information retrieval commu...

Ngày tải lên: 30/03/2014, 21:20

... dimers, with mono- mers A and B in dimer 1 and C and D in dimer 2 (Fig. 8). The a-crystallin domain of each monomer is composed of nine b-strands (labeled b2–b10), with the b6 strand situated in a large ... formation depends upon contact of b-strand 10 from the C-ter- minal extensions of monomers A and D with b-strands 4 and 8 in the a-crystallin domain of monomers C and B, respec...

Ngày tải lên: 07/03/2014, 12:20

... Treatment with small interfering RNA affects the microRNA pathway and causes unspecific defects in zebrafish embryos Xiao-Feng Zhao, Anders Fjose, Natalia Larsen, Jon V. Helvik and Øyvind Drivenes Department ... efficiencies of different siRNAs and related RNA molecules in inducing MMB defects. asGFP, antisense strand of GFP; dsGFP, double-stranded GFP without 3¢-overhangs; sGFP, sense s...

Ngày tải lên: 16/03/2014, 06:20

... evidence that complex size and chaper- one activity are linked. Mutations, and N- and C-terminal truncations of B. japonicum class A and class B proteins, which led to smaller complexes, were accompanied ... temperature- and concentration-dependent dissociations were fully reversible. Complexes formed between sHsps and the model substrate citratesynthasewerestableandexceededthesiz...

Ngày tải lên: 23/03/2014, 12:20

... Carbohydrate, glycolysis Lactococcus lactis Modeling Pi explicitly and regulation of pyruvate kinase (by Pi and FBP), PFK (by PEP) and GAPDH (by NADH) are critical to describe observations (rapid increase in PEP, Pi and gradual decrease ... metabolite concentrations and metabolic fluxes, both measured and nonmeasured. A general parameter sensitivity analysis is carried out to deter...

Ngày tải lên: 14/02/2014, 14:20

... H4-K5, K8 and K12 acetylation [136–138]. In yeast, this group is made up of NuA4 and Piccolo NuA4 which both uti- lize Esa1 as the HAT, and Esa1 was found to be essen- tial for H4-K5, K8 and K12 ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcription factor...

Ngày tải lên: 14/02/2014, 18:20

... tumors and cell lines, miR-17- 5p and miR-20a are induced in a manner that depends on cyclin D1 and repress the expression of cyclin D1. Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback loop and ... transcription factors E2F and Myc but, in turn, miR-17-92 downregulates the expression of E2F and Myc [52]. In tumor progression, the tran- scription repressors ZEB1 and SIP1...

Ngày tải lên: 14/02/2014, 19:20

... cancer. DNMT 3A and 3B DNMTs 1, 3A, and 3B are key DNA methylation enzymes. Recent studies in human cells have demon- strated that PRC2 and DNMTs are physically and functionally linked [76], and that ... (Mathworks, Natick, MA, USA), we compared localization and strand direction between miRNAs and transcripts (Refseq genes and mRNAs). Intragenic and intergenic miRNAs were de...

Ngày tải lên: 14/02/2014, 19:20

... disease and that, when miR-1 is overexpressed in normal and infracted rat hearts, this results in a slowed conduction velocity, excessively prolonged repolarization and the induction of PVCs and ... arrhythmias. On the other hand, blocking miR-1 function with antisense oligoribonucleotides was found to normalize the expression of Cx43 and Kir2.1, prevent QRS and QT prolongation,...

Ngày tải lên: 14/02/2014, 19:20