Báo cáo khoa học: Global shape and pH stability of ovorubin, an oligomeric protein from the eggs of Pomacea canaliculata pot

... courses and effects of unlabeled ligands and low pH on the dissociation rates of [ 125 I]TC-PCSK9 (A) and [ 125 I]TC-PCSK9-D374Y (B) from HepG2 cells. Binding to equilibrium and removal of unbound ... 4A). In the presence of a high concentration of unlabeled wild-type PCSK9, the half- time of the rapid phase was reduced from 19 to 16 min and the half-time...

Ngày tải lên: 14/02/2014, 14:20

... membrane proteins (the hydropho- bic translocators) and one hydrophilic partner (also called the V antigen in Pseudomonas aeruginosa and Yersinia spp.; Figs 1 and 2) comprise the translocon, and ... cell membrane, although the nature of the cellular signal required and the mecha- nism of its transduction are still a matter of debate [14,15]. The third, major part...

Ngày tải lên: 14/02/2014, 22:20

... expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... end of the gene, where the zebrafish and human sequences appear to be quite diverse. Together with the well-conserved gene organization, there is a conservation of...

Ngày tải lên: 16/02/2014, 09:20

... according to the manufacturer’s instruction. Statistics The data are presented as means ± standard errors of the mean (SEMs), and were statistically analyzed by means of the unpaired t-test or the Welch ... muscle with organ, but without fat, of WT and H-PGDS TG mice (n = 6). Continuous dissections of mouse fat and bone in the whole body were quantified by use of a...

Ngày tải lên: 16/02/2014, 09:20

... Y5 and y6) that vary in their binding profiles and in their distribution in the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of ... stromal cells and osteoblasts [40,46–48], despite the absence of the other Y receptors (Y2, Y4, Y5 and y6) [40,46]. In addition to the presence of NPY-immunoreactive...

Ngày tải lên: 18/02/2014, 04:20

... absorption spectrum of the purified enzyme was typical of the hydroxycobalamin form of the enzyme (Fig. 2). The recovery of the activity was  10%, and the enzyme was purified 3669-fold. The specific activity and ... addition of the FMN domain of MSR along with AqCbl and MeCbl caused a 6-fold and 20-fold stimulation of hMS activity. The presence of NADPH...

Ngày tải lên: 18/02/2014, 08:20

... Expression of GmPDIL-3a and GmPDIL-3b in soybean tissues. (A) Purified recombinant GmPDIL-3a (lanes 1 and 4), GmPDIL-3b (lanes 2 and 5) and proteins extracted from the cotyle- don (lane 3) were analyzed ... Japan Introduction Secretory, organelle and membrane proteins are synthe- sized and folded with the assistance of molecular chap- erones and other folding factors in...

Ngày tải lên: 18/02/2014, 11:20

... elevated, and consequently, the levels of nuclear SREBP-1c protein and lipogenesis are enhanced in the liver and adipose tissues. Intake of energy molecules such as sugars, carbohydrates and saturated ... apparatus, where the site 1 and site 2 proteases cleave the SREBPs [3,4]. Upon restoration of cellular cholesterol, Insig, another key regulator of ER membrane pr...

Ngày tải lên: 18/02/2014, 13:20

... dinophysistoxins and ana- logs) affect Ser ⁄ Thr protein phosphatases and their effects on cell adhesion and cytoskeletal dynamics, the disruption of which is linked to loss of cell polarity, and ... promoter and the biological significance of Ser ⁄ Thr and Tyr protein phosphatases have been extensively investigated in cancer-related research. The hyperphosphorylati...

Ngày tải lên: 18/02/2014, 14:20

... Ca 2+ into the cells because of the intracellular Na + influx and membrane depolarization; and (c) an as yet unidentified pathway that is independent of changes in membrane potential or changes in pH [9]. The ... spectrin, actin and ankyrin [48,49], and even regulation of Na + pump activity might depend on its linkage to the actin filament system [50,51]. In any case,...

Ngày tải lên: 18/02/2014, 14:20