Báo cáo khoa học: Structure and function of KH domains docx

... interface between the b-sheet of KH1 and the a-helices (a¢ and a2) of KH2 (Fig. 2B). By contrast, in hFMRP (KH1 KH2 D), the a¢-helix of KH1 is linked to the b1-strand of KH2 by the single residue, ... Within a family of KH proteins with multiple KH domains (i.e. type I KH domains) , the KH1 domain is always more similar to other KH1 domains in different pro- te...

Ngày tải lên: 07/03/2014, 05:20

... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130]. However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcript...

Ngày tải lên: 14/02/2014, 18:20

... (1990) The structure and function of the aspartic proteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 189–215. 2. Dunn, B.M. (2002) Structure and mechanism of the pepsin-like family of aspartic ... by the prosegment, but also by the 13 residues of the N-terminal of the mature enzyme and by the ÔflapÕ. The anchorage of the prosegment and of part of the N-terminus i...

Ngày tải lên: 19/02/2014, 12:20

... the glucokinase model using RasMol software. Figure 5 shows the predicted structure of GlcNAc kinase with the localiza- tion of the five ATP-binding subdomains and the secondary structures common to glucokinase. ... hexokinase and glucokinase, revealed a strong homology of the three enzymes [9]. In the present study, comparison of GlcNAc kinase with a model of the three-dimensi...

Ngày tải lên: 08/03/2014, 10:20

... form and function of novel complexes such as HAMLET and ELOA, we have provided new evidence that a loss of native structure can endow proteins and their complexes with distinct and beneficial functions substantially ... ago and since then the HAMLET field has widened in scope, acquiring new members and enriching our understanding of the basic principles underlying protein...

Ngày tải lên: 29/03/2014, 21:20

... (rmsd of 1.6 A ˚ for 1192 Ca atoms of a tetramer and 1.44 for 306 Ca atoms of a monomer). This indicates that not only is the monomer structure conserved, but also the quaternary structure of the tetramer. ... values of r 2 and sum of squares ( · 10 )3 ) were as follows: citrate, competitive 0.92 and 518 versus noncompetitive 0.95 and 351; isocitrate, competitive 0.98...

Ngày tải lên: 30/03/2014, 10:20

... Functional Analyses from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and CREST and BIRD projects of JST (Japan Science and Technology Agency). References 1 Segal ... domain structures of Noxo1 and the location of the five-amino-acid insertion in the PX domain. SH3, Src-homology 3 domain; PRR, proline-rich region. (C) Sequence alignments of...

Ngày tải lên: 19/02/2014, 06:20

... steps of ribosome biogenesis and ⁄ or ribosome function. Indeed, a systematic study of the incorporation of RPs into preribosomes led to the identification of the in vivo assembly pathway of the ... of RP mRNA for adjustment of the biosynthesis of ribosomes to the requirements of cell growth and differentiation. In addition, a relevant contribution of protein turnover...

Ngày tải lên: 07/03/2014, 01:20

... a-helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and Mg 2+ ) and of Dom-a¢ of a neighbouring subunit (pyrimidine moiety). ... consists of the three domains Dom-a, Dom-b and Dom-c (Fig. 2), named as in pre- vious annotations. All three domains consist of a cen- tral six-stranded paral...

Ngày tải lên: 07/03/2014, 12:20

... shifts for DMT1-TM4 in TFE and SDS. Ó FEBS 2004 Structure and topology of TM4 of DMT1 (Eur. J. Biochem. 271) 1951 Structure and topology of the transmembrane domain 4 of the divalent metal transporter ... Synthesis and biophysical analysis of transmembrane domains of a Saccharo- myces cerevisiae G protein-coupled receptor. Biochemistry 39, 15462–15474. Ó FEBS 2004 S...

Ngày tải lên: 16/03/2014, 16:20