... withbinding of both MOF and Tip60 (equivalent to Esa1in yeast NuA4) [124,130]. However, in human cellsdepletion of MOF, but not Tip60, results in reducedglobal levels of AcH4-K16 and defective ... acetylation and deacetyla-tion, and transient recruitment of remodellers and transcription factors.A cycle of transcription commences with the recruit-ment of transcription factors and co-factors ... FEBSMINIREVIEW Structure and function of active chromatin and DNase I hypersensitive sitesPeter N. CockerillExperimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds,...