Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot

... MINIREVIEW Parkinson’s disease: genetic versus toxin-induced rodent models Mu ¨ gen Terzioglu 1 and Dagmar Galter 2 1 Department of Laboratory ... available tissue-specific knockout mouse models with older genetic and toxin- induced animal models (Fig. 1). Toxin-induced animal models Early animal models developed for PD research used neurotoxins ... or by genetic ma...

Ngày tải lên: 07/03/2014, 05:20

... inclusions are evident in the huntingtin exon 1 mouse models and other small-fragment HD models [12,13], they can become cleared in conditional expression models cor- recting the disease phenotype to ... full-length huntingtin HD genetic mouse models, aspects of the disease phenotype seem more similar to the human disease, with the exception of specific stria- tal cell loss. These m...

Ngày tải lên: 23/03/2014, 07:20

... MINIREVIEW Huntington’s disease: degradation of mutant huntingtin by autophagy Sovan Sarkar and David C. Rubinsztein Department of Medical Genetics, University of Cambridge, Cambridge ... disease; lithium; mTOR; polyglutamine; rapamycin Correspondence S. Sarkar, Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, ... 122...

Ngày tải lên: 23/03/2014, 07:20

... apoptotic pathway and altered gene expres- sion observed in Hippi-expressing cells and cellular models, animal models or brains of HD patients. The transcriptional deregulation observed in a variety ... neuro- nal intranuclear inclusions. Aggregates ⁄ neuronal intra- nuclear inclusions are observed in cell models, brains of transgenic animals, and post-mortem brains of HD patients [2]. Ag...

Ngày tải lên: 23/03/2014, 07:20

... An Iterative Algorithm to Build Chinese Language Models Xiaoqiang Luo Center for Language and Speech Processing The Johns Hopkins University ... al., 1983), it is necessary to build a language model(LM) for as- signing probabilities to hypothesized sentences. The LM is usually built by collecting statistics of words over a large set ... better than a character- based 1 one. In addi...

Ngày tải lên: 31/03/2014, 06:20

... MINIREVIEW Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? Julia C. Fitzgerald and Helene ... 2008) doi:10.1111/j.1742-4658.2008.06708.x Rare, inherited mutations causing familial forms of Parkinson’s disease have provided insight into the molecular mechanisms that underlie the genetic and sporadic forms of thi...

Ngày tải lên: 18/02/2014, 14:20

... pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease Jose Bras 1,2 , Andrew Singleton 1 , Mark R. Cookson 3 and John Hardy 4,5 1 Molecular Genetics ... (2006) Genetics of Parkinson’s disease: para- digm shifts and future prospects. Nat Rev Genet 7, 306– 318. 2 Hardy J, Cai H, Cookson MR, Gwinn-Hardy K & Singleton A (2006) Genetics o...

Ngày tải lên: 18/02/2014, 14:20

... to handle time, belief contexts (based on a syntactic theory of belief [Haas, 1982]), simple hypothetical reasoning, and a representation of plans. Because the matcher is defined by a set of

Ngày tải lên: 21/02/2014, 20:20

... find that DEviaNT has 12% higher precision than that of baseline classifiers that use n-gram TWSS models. The rest of this paper is structured as follows: Section 2 will outline the characteristics ... in” or “[subject] could eat [object] all day” is more likely to be a TWSS than not. Thus, we hypothesize that machine learning with euphemism- and structure-based features is a promising approa...

Ngày tải lên: 07/03/2014, 22:20

... properties and redox potentials [68]. For wild-type BBE, a very high redox potential of +132 mV was found, whereas the C166A mutant exhibited a redox potential of +53 mV. The difference in potential was ... mutant Table 3. Redox potentials of covalent flavoproteins and their corresponding mutants containing noncovalently bound flavin. Wild-type protein Midpoint potential (mV) Mutation Midpoint...

Ngày tải lên: 16/03/2014, 01:20