Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc

... is an anticancer toxin that consists of a chemical conjugate between the human uPA and native saporin. Both saporin and uPA -saporin enter the target cell by endo- cytosis and must then escape the ... Unfortunately, saporin passage into the cytosol remains a poorly understood process. Both saporin and anticancer saporin conjugates enter the target cell by...

Ngày tải lên: 07/03/2014, 05:20

... meaningful chance of reanimation [8]. Some reasons why this occurs are as follows: 1. Physicians tell surrogates that they can make any decision they want as an open-ended ideal. This puts them ... suspended animation; they are not alive in the sense the we enjoy life but neither are they able to die as long as nutrition, hydration, ventilation, and perfusion are assured. In many ca...

Ngày tải lên: 25/10/2012, 10:45

... similar K m values of the native and WT, and the YQ mutant CPU with a synthetic and physiological substrate of CPU. There seem to be no major changes in the positioning of the propeptide, as ... on the basis of their model of human CPU, that the two consecutive I at positions 204 and 205 are exposed to the surface, and because they are quite unique to CPU,...

Ngày tải lên: 07/03/2014, 12:20

... fragment accompanied by the appear- ance and an increase in the 80 kDa fragment (Fig. 2). Although both the untransfected cells and the cells transfected with the vector alone started to show the 80 ... approved by the Institutional Animal Care and Use Committee of the Center South Uni- versity, and were carried out in accordance with the National Institutes...

Ngày tải lên: 16/02/2014, 09:20

... included a DNase I treatment, and cDNA synthesized as described above. The time points analyzed were 1–2 and 4–5 days pre-vitellogenesis, and 6, 12, 24, 36, 48 and 72 h PBM. To standardize qPCR inputs, ... deaths annually (http://www.who.org) and dengue, a rapidly expanding disease in most tropical and subtropical areas of the world, has become the most significant arbovir...

Ngày tải lên: 18/02/2014, 13:20

... on SDS ⁄ PAGE. Lanes a and d, in the absence of both TnC and Ca 2+ ; lanes b and e, in the presence of TnC and the absence of Ca 2+ ; lanes c and f, in the presence of both TnC and Ca 2+ . Ac, ... ATnI 130)252 , and ATnI 232)292 did not migrate into the gels, while free ATnI-52K and ATnI 1)128 exhibited a band near the origin and at the middle of the...

Ngày tải lên: 20/02/2014, 01:20

... E  s , with d x .d de- noting the index of the word that is the descendant in d x and d x .a denoting the ancestor. We define the following matching function to match the pair of de- scendants (or ancestors): match d (d e , ... defined analogously for ancestors. That is, match d (d e , d s ) returns true if the morph of the descendant of d e is the same as the m...

Ngày tải lên: 20/02/2014, 09:20

... interaction between ClpS and the N-domain of RR ⁄ AA, and this result suggests that neither the local nor the overall structure of the RR ⁄ AA mutant was compromised. Mutation of the conserved arginine ... Error bars represent the standard error of the mean. A non-specific protein band is indicated by an asterisk. (D) The functional interaction between ClpS and...

Ngày tải lên: 07/03/2014, 05:20

... be the subject of the clause. This ap- plies to about half of all the instances where the function of the relative pronoun is ambiguous. 2. On the other hand, if the form of the sub- stantive ... identical to the ac- cusative in the feminine singular of der and welcher, in the neuter singular of der, welcher and was, and in the plural (all gende...

Ngày tải lên: 07/03/2014, 18:20

... only the part -of- speech tags and grammar information are considered. The left hand side of the figure shows the original structure of the sen- tence, and the right hand side shows the trans- formed ... and reduce the number of levels in the hierarchy. This paper considers the tasks of identifying the syntactic structure of text chunking and gram- mar p...

Ngày tải lên: 08/03/2014, 02:21