Báo cáo khoa học: Thermodynamic stability and folding of proteins from hyperthermophilic organisms doc

... [1]. Comparisons of the thermodynamics and kinetics of the folding of proteins from mesophilic and thermo- philic ⁄ hyperthermophilic organisms can provide an insight into the mechanisms of stabilization ... 4033 MINIREVIEW Thermodynamic stability and folding of proteins from hyperthermophilic organisms Kathryn A. Luke 1,2 , Catherine L. Higgins 3 and...

Ngày tải lên: 07/03/2014, 05:20

... inferred from a cover of only 48 examples out of the 92 variants in the corpus. The active corpus treated separately requires 38 examples out of 46 and the passive corpus requires 28 out of 46. ... variants cover all standard legal permutations of tense, aspect, and voice, in- cluding do support and nine models. We simply use the surface forms, which are strings of...

Ngày tải lên: 24/03/2014, 01:21

... extraction and generation tech- niques to produce summaries of reviews of individual songs. We present an intrinsic evaluation of the extraction components, and of the informativeness of the sum- maries; ... sum- marization of reviews. We identify a string of words as the title of a song to be extracted from an album review if it (1) includes some or all the words in the...

Ngày tải lên: 20/02/2014, 04:20

... understanding of the folding and assembly processes of large multimeric or multidomain proteins remains a major problem in protein science and engi- neering. The folding of multidomain proteins ... the folding and stability of PARN. Recently, we have found that the unfolding of PARN by guanidine hydrochloride (GdnHCl) may be a multistage process. Unfortunately, the...

Ngày tải lên: 23/03/2014, 04:21

... studies of protein folding have been carried out, and major insights into the nat- ure of protein -folding mechanisms, including structural, kinetic and thermodynamic analyses of intermediates and ... native state on a sub-second timescale and have been the focus of many experimental and theoretical studies of folding [5]. The folding landscape of these protein...

Ngày tải lên: 23/03/2014, 11:20

... character of thermal denaturation of this protein at acidic and basic pH. The dependence of the conformational stability of porcine BLG on pH is analysed and discussed in comparison with that of bovine ... Thermograms of native (1) and renatured (2) porcine BLG at pH 9.0 (A) and pH 3.0 (B). Fig. 5. Thermograms of porcine (1) and bovine (2) BLG at pH 9.0 (A) and pH...

Ngày tải lên: 23/03/2014, 21:21

... development of Friedreich’s ataxia may result from a combination of reduced efficiency of protein folding and accelerated degradation in vivo, leading to lower than normal concentrations of frataxin. ... rest of the molecule, in agreement with the larger rmsd of the solution bundle in these regions [14]. Residues in the loop between strands b4 and b5 (Thr149, Asn151 and L...

Ngày tải lên: 30/03/2014, 04:20

... of lipo- proteins, and there was a corresponding increase in the binding of [ 125 I]TC-PCSK9 and [ 125 I]TC-PCSK9- D374Y. Second, the extent of specific binding of both [ 125 I]TC-labeled ligands ... the presence of a high concentration of unlabeled wild-type PCSK9, the half- time of the rapid phase was reduced from 19 to 16 min and the half-time of the slow phase was...

Ngày tải lên: 14/02/2014, 14:20

... expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... the expression of these genes within humans and mice, of T-bet within Ginbuna crucian carp [27] and STAT6 in mandarin fish [28] have shown similar widespread expression. I...

Ngày tải lên: 16/02/2014, 09:20

... S1. Comparison of intron–exon structures of GmPDIL-3a, GmPDIL-3b and orthologs of other plants. Fig. S2. Multiple amino acid sequence alignment of GmPDIL-3a, GmPDIL-3b and orthologs of other plants. Fig. ... organelle and membrane proteins are synthe- sized and folded with the assistance of molecular chap- erones and other folding factors in the endoplasmic reticulum...

Ngày tải lên: 18/02/2014, 11:20