Báo cáo khoa học: Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin pptx

... al. Formation of amyloid beta oligomers by prefoldin FEBS Journal 275 (2008) 5982–5993 ª 2008 The Authors Journal compilation ª 2008 FEBS 5993 Formation of highly toxic soluble amyloid beta oligomers by ... Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci 6, 11–22. M. Sakono et al. Formation of amyloid beta oligomers...

Ngày tải lên: 07/03/2014, 04:20

... The rPAB showed an apparent molecular mass of  60 kDa, similar to the native pulchellin. The toxic activities of the rPAB and native pulchellin were compared by intra- peritoneal injection of ... RIPs due to their potential role in the development of therapeutic agents. Perhaps the most promising approach to apply- ing RIPs in therapy is the use of immunotoxins...

Ngày tải lên: 07/03/2014, 16:20

... comparing the in silico tryptic digest of the translated amino acid sequence with the list of masses of tryptic peptides obtained by the MALDI-TOF analysis. In total, nine peptides from the list of ... translation is under the second nucleotide of the corresponding codon. The masses of underlined peptides correspond to the masses of tryptic peptides (Table S2...

Ngày tải lên: 29/03/2014, 08:20

... possible in part by grants from the Program of Basic research of the Presidium of RAS ‘Presidium of the Russian Academy of Sciences (Molecular and Cell Biology Program 10.5)’, from the Russian Foundation ... with RecA under the condition used (data not shown), and the best of them d(pT) 20 was used for the rest of the study. At the RecA monomer: ODN ratio...

Ngày tải lên: 30/03/2014, 16:20

... apoptotic effect). Both pathways require the translocation of ETA into the cytoplasm of toxin-treated cells. On the basis of the reconstitution of the cytotoxic pathways with in vitro cytosol and ... EF-2 on the one hand, and the mitochondrial membrane on the other hand. However, the potential role (if any) of ADP-ribosylation of EF-2 in the mitochondrial apopt...

Ngày tải lên: 18/02/2014, 04:20

... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding ... of pGL3–basic vector and was half that of pGL3–promoter vector. These findings demonstrate the promoter activity of the 5¢-flanking region of exon 1 in...

Ngày tải lên: 19/02/2014, 06:20

... homology 1 domain of all Smads binds to importin-b in the case of Smad3 and importin-a in the case of Smad4, while mutation of the NLS blocks the ability of these proteins to enter the nucleus [95–98]. ... Smad trafficking – the role of the Ran GTPase Most current evidence on the mechanisms that govern the dynamic shuttling of Smad proteins in the cell is base...

Ngày tải lên: 07/03/2014, 01:20

... increase the concentrations of the more toxic low -molecular- mass species. If the amyloid deposits are less toxic than the oligomeric TTR species, decreasing the concentra- tion of the amyloid ... the concentration of the oligomeric species were also decreased. Mechanism of neurotoxicity in FAP: the lesson from other amyloidoses A number of studies have e...

Ngày tải lên: 07/03/2014, 10:20

... cDNA of LEPRb, phosphorylation of STAT1, STAT3, STAT5 and the ERK kinases was induced by leptin. The weak response of STAT5 to leptin compared to that elicited by GH can be partially explained by ... partially explained by the rather ineffec- tive transfection of the HIT-T15 cells (estimated at 10–20% of transfected cells). Cells expressing the short splice variant...

Ngày tải lên: 07/03/2014, 16:20

... over the active site. They undergo structural changes on binding of the inhibitor molecule. In the unliganded protease structure, the conformation of the flaps is open, thereby exposing the active ... conser- vative and limited. The binding capacity of the S3/S3¢ sites was exploited by elongation of the compounds with groups in the P3/P3¢ positions or by extensi...

Ngày tải lên: 08/03/2014, 02:20