Báo cáo khoa học: Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment pptx

... pro-inflam- matory mediators is probably a result of the fact that inflammatory transcription factors such as nuclear factor-kappaB, activator protein-1 and nuclear factor of activated T-cells are ... factor-alfa (TNF -a) [43]. Taken together, these findings point to basal PARP-1 activity as central to homeostatic regulation of endothelial function, whereas its hyperactivation appe...

Ngày tải lên: 07/03/2014, 03:20

... years as a result of the expansion of the Aedes aegypti mosquito to dif- ferent geographic areas, and DHF has spread from South East Asia to the Western Pacific and the Americas. A substantial ... cytotoxic epitopes of the others [63]. The major pharmaceutical companies are currently developing a treatment against the disease. A tetra- valent live attenuated vacci...

Ngày tải lên: 19/02/2014, 00:20

... 5¢-CGAGCCAAGTCGCTGCAAACGCT AATACCG-3¢ as a reverse primer. GAPDH gene was ampli- fied as a negative control. The primers used were 5¢-TGG TATGACAACGAATTTG-3¢ as a forward primer and 5¢- TCTACATGGCAACTGTGAGG-3¢ as ... oxyge- nase gene. J Biol Chem 262, 6795–6802. 53 Udono T, Yasumoto K, Takeda K, Amae S, Watanabe K, Saito H, Fuse N, Tachibana M, Takahashi K, Tamai M et al. (2000...

Ngày tải lên: 16/03/2014, 13:20

... SDS to aid solubilization of brain d-catenin. The extract was clarified by centrifugation at 40 000 g and the supernatant passed through a GST-affinity column. The flow-through was applied to a GST ... contact one another through their extracellular domains. The intracellular domains anchor the junc- tional complex or adherens junction to the actin cyto- skeleton via the...

Ngày tải lên: 16/03/2014, 22:20

... directed to the basolateral surface. From our data, it remains unclear by what mechanism gap junctional plaques are retained at the basolateral surface. We found that the ODDD-associated L90V mutant disrupts ... both the apical and basolateral compartments of the culture dishes. The MDCK cell monolayer provides a barrier between the apical and basolateral compartments. The...

Ngày tải lên: 23/03/2014, 04:20

... USA Introduction Upon catalyzing the cleavage of RNA, RNases operate at the crossroads of transcription and translation. Bovine pancreatic RNase A (EC 3.1.27.5) is the best characterized RNase. A notoriously stable ... Discussion Sulfonimides as inhibitors of RNase A We began by determining the ability of three backbone analogs of RNA to inhibit catalysis by RNase A. These...

Ngày tải lên: 14/02/2014, 22:20

... acetyl-CoA car- boxylase; AMPK, 5¢ AMP kinase; CPT, carnitine palmitoyltransfer- ase; FAS, fatty acid synthase; MCD, malonyl-CoA decarboxylase; OAA, oxaloacetate; TCA, tricarboxylic acid. M. J. Wolfgang ... [41–45]. There are at least six carnitine acyltransferases in mammals [46]. Carnitine acetyltransferase and carni- tine octonyltransferase mediate the transfer of acetyl and short- to...

Ngày tải lên: 14/02/2014, 22:20

... unambiguously showed the protein to be tetrameric. The calculated molecular mass based on DLS data was 73 kDa, and corresponds reasonably with the predicted molecular mass of 64.4 kDa for the Bxe _A2 876 homotetramer. The ... indicates that the Fe 2+ bound to Bxe _A2 876 is coordinated by a total of five ligand atoms. An initial estimation of the first coordination shell of...

Ngày tải lên: 18/02/2014, 06:20

... with bacterial DNA as a potential regulator. Nat Med 7, 180–185. 40 Chakraborty K, Ghosh S, Koley H, Mukhopadhyay AK, Ramamurthy T, Saha DR, Mukhopadhyay D, Roychowdhury S, Hamabata T, Takeda Y ... Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K et al. (2007) Antimicrobial peptides human beta- defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular ....

Ngày tải lên: 18/02/2014, 06:20

... characteristics and hyper- anticoagulant activity. Binding ability was established using a SPR membrane binding assay and anticoagu- lant activity was assessed by a thrombin generation assay. The ... historically known for its role in anticoagulation, APC was recently revealed to have cytoprotective, anti-inflammatory and anti-apoptotic functions. These new functions of APC are related...

Ngày tải lên: 18/02/2014, 06:20