Báo cáo khoa học: Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes ppt

... Authors Journal compilation ª 2008 FEBS 131 Proteomic analysis reveals Hrs ubiquitin- interacting motif-mediated ubiquitin signaling in multiple cellular processes Julia W. Pridgeon*, Elizabeth A. ... and ubiquitin binding of the ubiquitin- interacting motif.J Biol Chem 278, 28976–28984.12 Miller SL, Malotky E & O’Bryan JP (2004) Analysis ofthe role of ubiquitin- interacting motifs in ubiquitin ... enzymesinvolved in ubiquitination and metabolism, suggesting the involvement of Hrs UIM-mediated ubiquitin signaling in the regulation of multiple cellular processes. We have characterized the ubiquitination...

Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

... expression pattern of cellular proteins in the human catecholaminergic neuroblastoma cell lineSH-SY5Y, overexpressing a-synuclein. A proteomic analysis is expected to identify cellular alterationsthat ... dopamine treatment, overexpres-sion of a-synuclein signiﬁcantly affected the levels offour proteins [stathmin 1, glutathione S-transferase(GST)p, Ran 1 binding protein and C1q binding pro-tein], ... obtained from ppi spider starting fromthe proteins grouped as above (Tables S2 and S3). In both cases, bioinformatic analysis revealed thatthe NF-jB pathway could be involved in determiningthe...

Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"

... PowerBlot analysis showed altered expression of many proteins involved in apoptosis, including the expression profiles of proteins involved in the mito-chondrial (bcl-2, bax, and bcl-x, etc.) and ... As shown in Fig. 3, 12hr exposure to hypoxia caused almost no increase in the phosphory-lated JNKs protein level in the cell line. Twenty-four-hour exposure to hypoxia resulted in a Int. J. ... protein changes for the experimental sample to control detected by using the Odyssey Infrared Imaging System. (+) means an increase of signal intensity, and (-) means a decrease of signal intensity...

Báo cáo khoa học: "Morphological Analysis of a Large Spontaneous Speech Corpus in Japanese" pptx

... points in F-measure. The fourth line in Tables 6 shows thattransformation rules signiﬁcantly contributed to im-proving the accuracy.Considering the results obtained in this sectionand in ... morphemes in as-cending order of their probabilities as estimated bythe proposed models. In our experiments, only the information con-tained in the corpus was used; however, more appro-priate linguistic ... Dictionary. In Proceedingsof EMNLP, pages 91–99.K. Uchimoto, C. Nobata, A. Yamada, S. Sekine, and H. Isahara.2002. Morphological Analysis of The Spontaneous SpeechCorpus. In Proceedings of COLING,...

Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx

... protein fun ction in other genes where it can in uence many cellular processes including signal transduction, transcriptional regulation, cellular transformation and subcellular l ocalization in ... Accord-ingly, the majority of alterations in 63 kDa protein mass in multiple cellular contexts identiﬁed here in are mediatedpredominantly by transcriptional r egulation. We speciﬁcallypoint out ... doi:10.1111/j.1432-1033.2004.04435.xrate-determining factor in uncoupling protein (UCP) activ-ity [16]. Thus, t he role of mitochondrial i PLA2activities in regulating mitochondrial function is just now beginning tobe understood....

Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

... residue-longproteins lacking disulﬁde bridges. Type II cystatins,cystatins C, D, E ⁄ M, F, S, SA, SN are longer extra- cellular proteins, consisting of % 120 amino acid resi-dues and containing two ... bridges. Type IIIcystatins, the kininogens, are large multifunctionalplasma proteins, containing three type II cystatin-likedomains.Cystatin F was discovered recently by three inde-pendent groups. ... cystatin F containing endosomal ⁄ lysosomal vesicles.The ﬁnding that cystatin F was not colocalized with cystatin C suggestsdistinct functions for these two cysteine protease inhibitors in U937...

Tài liệu Báo cáo khoa học: "Names and Similarities on the Web: Fact Extraction in the Fast Lane" ppt

... Extraction in the Fast LaneMarius Pas¸caGoogle Inc.Mountain View, CA 94043mars@google.comDekang LinGoogle Inc.Mountain View, CA 94043lindek@google.comJeffrey Bigham∗University of WashingtonSeattle, ... NNP IN NNP NNP VBD VBN NNP CD , CD .InfixfoundfoundChester Burton Atkins was born June 20 , 1924 , on a farm near Luttrell . NNP NNP NNP VBD VBN NNP CD , CD , IN DT NN IN NNP .InfixInfixfoundThe ... child of three siblings , Mariah Carey was born March 27 ,1970 in Huntington , Long Island in New York . DT JJS NN IN CD NNS , NNP NNP VBD VBN NNP CD , CD IN NNP , JJ NN IN NNP NNP .foundfoundfound(S1)(S2)(S3)(S4)(S5)(Jethro...

Báo cáo khoa học: Leishmania donovani methionine adenosyltransferase Role of cysteine residues in the recombinant enzyme pptx

... donor of propylaminegroups in the metabolism of spermidine and spermine [2]and an intermediary in the trans-sulfuration pathway tocysteine, one of the three amino acids involved in glutathi-one ... cysteine compositions in the central domain lackthe homologous mammalian enzyme amino acids atpositions 61 and 69 which are, in turn, involved in establishing the disulﬁde bond and proper folding ... of a 5-min cycle at 94 °C,followed by 12 cycles at 94 °C for 30 s, 55 °Cfor1minand68 °C for 12 min and ending with 10 min at 68 °C. PCR-products were incubated in presence of DpnIinordertodigest...

Báo cáo khoa học: "Dependencies between Student State and Speech Recognition Problems in Spoken Tutoring Dialogues" ppt

... its success. In our case, if we look at affect (FAH) or attitude (CERT) in isolation we find many interactions; in contrast, combining them offers little insight. 6 Results – insights & ... ‘Certain’ and ‘Anything Else’ (in this case Uncertain, Mixed and Neutral). By studying the dependency between binary variables we can understand how the interaction works. Table 2 reports in ... Skantze, 2005). In the second step, significant dependencies are combined to produce interesting insights regard-ing SRP and to propose strategies for handling SRP. Validating these strategies...

Báo cáo khoa học: Ion channel activity of brain abundant protein BASP1 in planar lipid bilayers pptx

... brain abundant myri-stoylated protein localized at the inner surface of the presynaptic plasmamembrane. Emerging evidence suggests that BASP1 is critically involved in various cellular processes, ... presum-ably involves the regulation of actin cytoskeletondynamics through either direct interaction with actin-binding proteins [30] or modulation of the plasmalemmaldistribution of phosphatidylinositol-4,5-diphosphate(PIP2) ... within180 min (starting from the protein addition). Thelatency time before the appearance of ion channelactivity was highly variable (in the range 30–120 min)and decreased with increasing...

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