... of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularlywithin the injured or diseased brain. In the case ... investigated whether GIFacts in a neuroinhibitory manner when administereddirectly into the brain following traumatic brain injury. In one such study, the injection of GIF into the site ofa stab wound ... suggesting that this MT isoform has different and distinct functions within the brain. Furthermore, the discovery and continued investigation of this brain-spe-cific MT isoform has led to intense interest...