Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram potx
Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram potx
... Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram Florence Malka, Julien Dairou, Nilusha Ragunathan, Jean-Marie Dupret and Fernando Rodrigues-Lima Universite ´ Paris ... of NAT1. Conditions % of control activity a NAT1 + DS 0.5 ± 0.7 NAT1 + DS + GSH (1 m M) 1. 2 ± 0.9 NAT1 + DS + GSH (2 m M) 1. 3 ± 0.6 NAT1 + DS + GSH (5 m...
Ngày tải lên: 07/03/2014, 02:20
Báo cáo khoa học: Folding and turnover of human iron regulatory protein 1 depend on its subcellular localization pdf
... media Strains W303-1B (mat a, ade2 1, ura3 1, his3 11 , trp1 1, leu2–3 ,11 2, can1 10 0), FYF4-A1 aco1 (mat a, ura3–52, trp1D63, leu2D1, his3D200, aco1::URA3), and BY4 7 41 (mat a, his3, leu2, met15, ura3) ... stained. Lane 1, recombinant human IRP1; lanes 2– 11 , fractions 1 10 of the sucrose gradient. (B) Western blot of the same fractions. Lane 1, recombinant human IRP1; l...
Ngày tải lên: 07/03/2014, 10:20
Báo cáo khoa học: Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition potx
... gcg) EP-40 C140S (t fi a), Q143A (cag fi gcg) DS -10 N73S (a fi g), K98 (a fi g), Q143A (cag fi gcg), D159 (t fi c) EP-46 N129D (a fi g), C140S (t fi a), Q143A (cag fi gcg) DS -11 K1N (g fi t), P16 (t fi c), C140S ... dismutation of superoxide [32]. A least-square fit of Eqn (1) to the data of Fig. 1 yields the constants given in the legend of Fig. 1. The values of k cat ⁄ K m and k cat fo...
Ngày tải lên: 07/03/2014, 11:20
Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens potx
... 0.98 01 0.9393 0.98 01 Resolution [A ˚ ] 20–2.6 20–2.6 20–2.6 20–2.6 Observables 598 889 598 513 429 583 324 789 Unique reflections a 15 6 252 (17 815 ) 15 6 058 (17 756) 14 3 633 (16 819 ) 79 796 (10 12 2) Completeness ... Biochim Biophys Acta: Proteins and Proteomics, doi :10 .10 16/j.bbapap2005. 08.025 (Received 5 August 2005, revised 22 September 2005, accepted 29 September 2005) d...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... (19 91) Crystal structure of human alpha-lactalbu- min at 1. 7 A resolution. J Mol Biol 2 21, 5 71 5 81. 15 Kuwajima K (19 96) The molten globule state of alpha-lactalbumin. FASEB J 10 , 10 2 10 9. 16 ... Anki.Mossberg@med.lu.se (Received 30 April 2 010 , revised 18 August 2 010 , accepted 2 September 2 010 ) doi :10 .11 11/ j .17 42-4658.2 010 .07890.x Human a-lactalbumin made...
Ngày tải lên: 29/03/2014, 21:20
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... 8639 E-mail: p.n.cockerill@leeds.ac.uk (Received 18 December 2 010 , revised 10 February 2 011 , accepted 5 April 2 011 ) doi :10 .11 11/ j .17 42-4658.2 011 .0 812 8.x Chromatin is by its very nature a repressive environment ... activity. Science 311 , 757. 12 2 Yang D & Arya G (2 011 ) Structure and binding of the H4 histone tail and the effects of lysine 16 acetylation....
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... NFIB MAPK, AP -1, NFIB, RASV12, ID -1 [18 ,64] miR -13 2 MeCP2 MeCP2 [65] miR- 61 VAV1 LIN -12 ⁄ Notch [26] A. Ichimura et al. miRNAs and cell signaling FEBS Journal 278 (2 011 ) 16 10 16 18 ª 2 011 The Authors ... gtsuji@pharm.kyoto-u.ac.jp (Received 10 November 2 010 , revised 6 February 2 011 , accepted 1 March 2 011 ) doi :10 .11 11/ j .17 42-4658.2 011 .08087.x MicroRNAs (miRNAs)...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt
... 2 010 , revised 27 June 2 010 , accepted 10 July 2 010 ) doi :10 .11 11/ j .17 42-4658.2 010 .07770.x To understand the potential paracrine roles of interleukin-1b (IL-1b), tumour necrosis factor-a (TNF-a) and ... of IL -1 beta and IL -18 in human blood. J Immunol 16 5, 4 615 –4623. 31 Mehta VB, Hart J & Wewers MD (20 01) ATP-stimulated release of interleukin (IL)-1beta...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... Biochem 64, 11 42 11 46. 10 Fernandez-Pol JA, Klos DJ & Hamilton PD (20 01) Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus -1 and human herpes ... (m M) Inhibition (%) Dihydroxyacetonephosphate 1 0.5 0 .1 100 10 0 70 3-Phosphoglycerate 1 0.5 0 .1 100 10 0 25 Glyceraldehyde-3-phosphate 1 40 Phosphoenolpyruvate 1 30...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... p53R2 97 0 1 M246V p53R2 56 0 1 C275S p53R2 223 0 1 Q192R WAF1 32 67 13 5 D208E WAF1 ⁄ MDM2 2 12 36–96 T256A WAF1 11 40–86 N263D WAF1 ⁄ MDM2 1 18 54 10 8 V272A WAF1 ⁄ MDM2 1 3 32–49 A276T WAF1 ⁄ MDM2 ... cavity. Parameter WAF1 MDM2 BAX 14 -3-3-r AIP GAD45 NOXA p53R2 Average A Conservation 16 24 25 30 27 21 15 21 22 Accessibility 22 15 7 14 16 27 31 43 22 Average calculated energ...
Ngày tải lên: 18/02/2014, 11:20