Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot

... has been investigated thoroughly in fibro- blasts such as H-ras transformed NIH3T3 fibroblasts, mouse embryo fibroblasts and Swiss3T3 fibroblasts [145–148]. In fibroblasts transformed by inducible expression ... ATGFβ Recycling Recycling AB C Fig. 1. Control < /b> of < /b> TGFb and activin ⁄ nodal receptor trafficking by small GTPases. (A) The role of < /b> Rab5 and Rab11 in TGFb receptor...

Ngày tải lên: 07/03/2014, 01:20

... inhibitor-1 (PAI-1) (Fig. 5). On the other hand, KLK5 was inhibited strongly by PAI-1 and a 2 -AP, but not by ACT and AT (Fig. 5). Pro-HGFA processing by both KLKs was potently inhibited by HAI-1KD1, ... to be much more potent at activating pro-HGFA than KLK4, and its specific activity was about half that of < /b> thrombin. In the absence of < /b> dextran sulfate, the pro- cessing o...

Ngày tải lên: 23/03/2014, 07:20

... 10.0 B chemical shift (ppm) Fig. 7. Bac kbone NH 1 H chemical shifts. Distribution (%, black bars) of < /b> backbone NH chemical shifts (p.p.m.) for f 5b (A) and f 6b (B) . The distribution of < /b> backbone ... fragment of < /b> alternating hydrophobic residues h as been shown to be recognized by BiP [36], a mammalian chaperone of < /b> the HSP70 family. Because the primary quali...

Ngày tải lên: 23/03/2014, 13:20

... Segatto O (2000) Inhibition of < /b> ErbB-2 mitogenic and transforming < /b> activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol Cell Biol 20, 7735–7750. 16 ... Numbers in round and square brackets represent the number of < /b> probe sets and the number of < /b> probe sets without gene IDs, respectively. Other numbers refer to the number...

Ngày tải lên: 30/03/2014, 01:20

... of < /b> thrombin selectively modulates inhibi- tion by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite deter- mines heparin cofactor II specificity. J Biol ... J Biol Chem 269, 14705–14710. FEBS Journal 272 (2005) 4842–4851 ª 2005 FEBS 4851 R. N. Pike et al. Control < /b> of < /b> the coagulation system by serpins MINIREVIEW Control < /b>...

Ngày tải lên: 20/02/2014, 02:21

... presence of < /b> amino acid(s) resulted in inhibition of < /b> the DNA binding of < /b> the involved transcription factors. By contrast, the presence of < /b> amino acid may also result in stimulation of < /b> the DNA binding of < /b> ... the major role played by ATF and C/EBP factors in the inhibiting effect of < /b> amino acids on gene expression. Concerning the stimulation of...

Ngày tải lên: 07/03/2014, 00:20

... intracellular accumulation of < /b> amyloid b- protein (Ab) in human neuroblastoma cells. Biochemistry 39, 6951–6959. 18 Blass JP, Baker AC, Ko L & Black RS (1990) Induction of < /b> Alzheimer antigens by an uncoupler of < /b> oxidative ... each group of < /b> cells was confirmed by Western blotting, an example of < /b> which is shown (bottom panel). Expression of < /b> b- tubu...

Ngày tải lên: 23/03/2014, 03:20

... regions may now be explained by the presence of < /b> highly labile H2A.Z ⁄ H3.3-containing nucleosomes that are easily displaced by TFs. This fact has been over- looked before because of < /b> H2A.Z ⁄ H3.3 ... specificity can be achieved (a) by utilizing different DNA methyltransferases to deposit the methyl mark and (b) by recognition of < /b> the mark by different DNA methyl bi...

Ngày tải lên: 28/03/2014, 22:21

... stopped by the addition of < /b> reducing SDS ⁄ PAGE buffer, and this was followed by SDS ⁄ PAGE and Coomassie Brilliant Blue staining or western blot analysis. ETA-catalyzed ADP-ribosylation of < /b> cytosolic ... adminis- tration of < /b> native ETA, and evaluated for their content of < /b> LRP1 (upper blot) or EEA1 (lower blot) by reducing SDS ⁄ PAGE followed by western blot an...

Ngày tải lên: 18/02/2014, 04:20

... levels of < /b> KLF4 were determined by real-time PCR. (B) Protein levels of < /b> KLF4 were determined by western blot. (C) mRNA levels of < /b> hSR-BI were determined by real-time PCR. (D) Protein levels of < /b> hSR-BI were ... immunoreactive bands were visualized using diamino- benzidine (DAB) (Boster Biological Technology, Wuhan, Hubei, China). The following antibodies were use...

Ngày tải lên: 18/02/2014, 04:20