Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
... FEBS. No claim to original French government works.REVIEW ARTICLE Control of mammalian gene expression by amino acids, especially glutamine Carole Brasse-Lagnel, Alain Lavoinne and Annie HussonAppareil ... Although the molecular mechanismsinvolved in the control of gene expression by amino KeywordsAARE; amino acids; ATF; gene transcription; glutamine; mammalian cells; NF-jB; NSRE;signalling pathways; ... sequencesfollowing amino acid deprivation, emphasizing themajor role played by ATF and C/EBP factors in theinhibiting effect of amino acids on gene expression. Concerning the stimulation of gene expression by...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... inducer of uPA gene expression [16].Decma-induced uPA gene expression isdependent on Erk activationWe and others have shown that activation of Erk playsan important role in uPA gene expression ... phos-phorylation. Moreover, expression of silent mutants of Shc isoforms showed that only p46Shcand p52Shcres-cued the effect of the siRNA. Overexpression of p66Shcnot only failed to ... indicated, followed by westernblotting for Shc, phospho-Erk and total Erk levels. (C) Rescue by ectopic Shc isoform expression of Erk activation that was suppressed by down-regulation of endogenous...
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Tài liệu Báo cáo khoa học: Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans pptx
... FEBS 4851R. N. Pike et al. Control of the coagulation system by serpinsMINIREVIEW Control of the coagulation system by serpinsGetting by with a little help from glycosaminoglycansRobert N. Pike1,2, ... Site-directedmutagenesis of arginine 103 and lysine 185 in theproposed glycosaminoglycan-binding site of heparincofactor II. J Biol Chem 265, 286–291. Control of the coagulation system by serpins ... order rates of association (kass) values for thereaction of serpins with proteases in the presence and absence of a range of GAGs (values are representative of those reported in arange of publications...
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Báo cáo khoa học: Control of nuclear receptor function by local chromatin structure doc
... independent of the gene expression [162,163].High CpG density promoters are associated withtwo classes of genes, commonly expressed housekeep-ing genes and highly regulated key developmentalgenes, ... 2A).Correlation of DHSs with gene expression hasshown that all expressed genes are marked by a DHSat the TSS [79]. However, although the presence of aDHS might be necessary for gene expression, it isclearly ... composed of palin-dromic repeats of a hexanucleotide sequence separated by three non-conserved base pairs with each HREhalf-site being bound by one receptor monomer[12,13].Out of the multitude of...
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Báo cáo khoa học: Ablation of Sax2 gene expression prevents diet-induced obesity docx
... food intake by suppressingthe expression of NPY mRNA and by activatingPOMC mRNA expression, whereas low levels activateNPY mRNA expression, which in turn inhibits the expression of POMC mRNA, ... path-ways are indirectly affected by a lack of Sax2 gene expression, most likely through an impairment of foodabsorption.ResultsComparison of body weight and food uptake of adult wild-type, Sax2 heterozygous ... affected by lack of Sax2 gene expression ABCDEFFig. 4. Analysis of blood glucose, insulin and leptin levels of female Sax2+ ⁄ +and Sax2) ⁄ )animals. (A) Blood glucose levels of Sax2+...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... in an increase in the number of binding sites and a decrease of the affinity of the uPAR[38,39]. The quantification of uPAR expression by mea-surement of the amount of uPA bound is thus not ideal.Actually, ... FEBS 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3957Suppression of urokinase receptor expression by bikuninis associated with inhibition of upstream targets of extracellularsignal-regulated ... studied the inhibition of uPAR expression by stable transfection of HRA cells withbikunin gene, demonstrating that bikunin secretion is nec-essary for inhibition of uPAR expression. We conclude...
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Báo cáo khoa học: Charging of tRNA with non-natural amino acids at high pressure potx
... acylated by AARS [31].Furthermore, it was shown that AARSs are able toutilize noncognate amino acids in the aminoacylation of CoA, and in the acylation of mini helix of RNA[32]. The equilibrium of ... Applica-tion of MS provides evidence that charging occurs atthe hydroxyl group of the 3¢-end ribose.ResultsTRNAPheaminoacylation with non-natural amino acids at high pressureAminoacylation of tRNAPheusing ... Time-dependent aminoacylation of tRNAwith tryptophan showed that the best result, 96 pmol of Tyr per 1600 pmol of tRNAPhe, was obtained after30 min of pressure at 6 kbar (Fig. 2). The yield of charging...
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Báo cáo khoa học: Induction of PAI-1 expression by tumor necrosis factor a in endothelial cells is mediated by its responsive element located in the 4G/5G site ppt
... blocked by antioxidants, it appears that the generation of ROSmay be involved in the induction of PAI-1 expression by TNFa via the activation of NF-jB.ResultsUpregulation of PAI-1 expression ... )680 of the PAI-1 promoter. This reaction involves the TNFa-induced generation of superoxide leading to activation of NF-jB, and canbe abolished by antioxidants and by overexpression of a super-suppressorphosphorylation-resistant ... Dependence of PAI-1 expression upon NF-jB activation. (A, B) Inhibition of PAI-1 antigen expression produced by incu-bation of TNFa-stimulated endothelial cellswith increasing concentrations of 26S...
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Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf
... Hsp105a, induces the expression of Hsp70 in mammalian cells.Here, we examined the mechanism by which Hsp105b induces the expres-sion of Hsp70. Using a series of deletion mutants of Hsp105b, it wasrevealed ... the nucleus and induces the expression of Hsp70 in mammalian cells [12,13]. To elu-cidate the mechanism by which Hsp105b induces the expression of Hsp70, a series of plasmids that expressedC-terminal ... for the Hsp105b-induced expression of the hsp70 gene. The promoter region between )206 and )187 bp of the hsp70 gene is essential for activation of the hsp70 promoter by Hsp105bTo identify the...
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Tài liệu Báo cáo khoa học: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation doc
... W(2004) Role of the kinase MST2 in suppression of apop-tosis by the proto-oncogene product Raf-1. Science 306,2267–2270.27 Valverde P (2000) Cloning, expression, and mapping of hWW45, a novel ... inFig. 5B, the coexpression of Sav with WT Mst1 orMst2 altered the mobility of Sav, as well as increasingits abundance. In contrast, coexpression of Sav withthe truncated mutants of Mst that were ... Chem 270, 21695–21700.2 Creasy CL & Chernoff J (1995) Cloning and characteri-zation of a member of the MST subfamily of Ste20-likekinases. Gene 167, 303–306.3 Lin JL, Chen HC, Fang HI,...
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