Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx

... FEBS. No claim to original French government works. REVIEW ARTICLE Control of mammalian gene expression by amino acids, especially glutamine Carole Brasse-Lagnel, Alain Lavoinne and Annie Husson Appareil ... Although the molecular mechanisms involved in the control of gene expression by amino Keywords AARE; amino acids; ATF; gene transcription; glutamine;...

Ngày tải lên: 07/03/2014, 00:20

... inducer of uPA gene expression [16]. Decma-induced uPA gene expression is dependent on Erk activation We and others have shown that activation of Erk plays an important role in uPA gene expression ... phos- phorylation. Moreover, expression of silent mutants of Shc isoforms showed that only p46 Shc and p52 Shc res- cued the effect of the siRNA. Overexpression of p66...

Ngày tải lên: 19/02/2014, 05:20

... FEBS 4851 R. N. Pike et al. Control of the coagulation system by serpins MINIREVIEW Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans Robert N. Pike 1,2 , ... Site-directed mutagenesis of arginine 103 and lysine 185 in the proposed glycosaminoglycan-binding site of heparin cofactor II. J Biol Chem 265, 286–291. Control of...

Ngày tải lên: 20/02/2014, 02:21

... independent of the gene expression [162,163]. High CpG density promoters are associated with two classes of genes, commonly expressed housekeep- ing genes and highly regulated key developmental genes, ... 2A). Correlation of DHSs with gene expression has shown that all expressed genes are marked by a DHS at the TSS [79]. However, although the presence of a DHS might be neces...

Ngày tải lên: 28/03/2014, 22:21

... food intake by suppressing the expression of NPY mRNA and by activating POMC mRNA expression, whereas low levels activate NPY mRNA expression, which in turn inhibits the expression of POMC mRNA, ... path- ways are indirectly affected by a lack of Sax2 gene expression, most likely through an impairment of food absorption. Results Comparison of body weight and food upta...

Ngày tải lên: 28/03/2014, 23:20

... in an increase in the number of binding sites and a decrease of the affinity of the uPAR [38,39]. The quantification of uPAR expression by mea- surement of the amount of uPA bound is thus not ideal. Actually, ... FEBS 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3957 Suppression of urokinase receptor expression by bikunin is associated with inhibition of...

Ngày tải lên: 17/03/2014, 11:20

... acylated by AARS [31]. Furthermore, it was shown that AARSs are able to utilize noncognate amino acids in the aminoacylation of CoA, and in the acylation of mini helix of RNA [32]. The equilibrium of ... Applica- tion of MS provides evidence that charging occurs at the hydroxyl group of the 3¢-end ribose. Results TRNA Phe aminoacylation with non-natural amino acids at high p...

Ngày tải lên: 30/03/2014, 10:20

... blocked by antioxidants, it appears that the generation of ROS may be involved in the induction of PAI-1 expression by TNFa via the activation of NF-jB. Results Upregulation of PAI-1 expression ... )680 of the PAI-1 promoter. This reaction involves the TNFa- induced generation of superoxide leading to activation of NF-jB, and can be abolished by antioxidants and by o...

Ngày tải lên: 30/03/2014, 11:20

... Hsp105a, induces the expression of Hsp70 in mammalian cells. Here, we examined the mechanism by which Hsp105b induces the expres- sion of Hsp70. Using a series of deletion mutants of Hsp105b, it was revealed ... the nucleus and induces the expression of Hsp70 in mammalian cells [12,13]. To elu- cidate the mechanism by which Hsp105b induces the expression of Hsp70, a...

Ngày tải lên: 18/02/2014, 06:20

... W (2004) Role of the kinase MST2 in suppression of apop- tosis by the proto-oncogene product Raf-1. Science 306, 2267–2270. 27 Valverde P (2000) Cloning, expression, and mapping of hWW45, a novel ... in Fig. 5B, the coexpression of Sav with WT Mst1 or Mst2 altered the mobility of Sav, as well as increasing its abundance. In contrast, coexpression of Sav with the truncated mutan...

Ngày tải lên: 19/02/2014, 06:20