Báo cáo khoa học: NO synthase isoforms specifically modify peroxynitrite reactivity pptx

... dimer; iNOS, inducible nitric oxide synthase; nNOS, neuronal nitric oxide synthase; NO, nitric oxide; NOS, nitric oxide synthase; NOSoxy, oxygenase domain of NOS; PN, peroxynitrite; RNS, reactive nitrogen ... PN additions, nNOSoxy and bsNOS lose their ability to activate PN decomposition, as observed for iNOSoxy [49]. 0 25 50 75 100 125 150 175 200 bsNOSnNOSoxyiNOSoxy Peroxynitrite re...

Ngày tải lên: 06/03/2014, 22:21

... and in vivo in ENaC-expressing Xenopus oocytes. The c subunit is weakly phosphorylated by this protein kinase on another residue (cT599), and the C tail of a is not significantly phosphory- lated ... either [ 35 S]methionine or 32 Pi. The b subunit could be specifically immunoprecipitated from oocytes by an anti-HA antibody (Fig. 4A). It was endogenously phosphorylated, and the amount of phos...

Ngày tải lên: 21/02/2014, 03:20

... Comp Endocrinol 131, 134–142. 47 Giulianini PG, Smullen R, Bentley MG & Ferrero EA (1998) Cytological and immunocytochemical study of the sinus gland in the Norway lobster Nephrops norvegi- cus. ... However, it is worth noting that the presence of a d-amino acid in CHHs from these last species may be overlooked because no specific investigation procedure, such as amino acid chiral analys...

Ngày tải lên: 18/02/2014, 11:20

... in the cyanobacterial ACs. In this context, it is noteworthy that the rat PDE2 (rPDE2) GAF tandem, which is almost identical with the mouse sequence, can functionally replace the cyanobacterial ... N 6 amino group. The inter- actions of the b2–b3 element with the purine appear to be rather distinct in rPDE2 GAF B, cyaB2 GAF A and cyaB2 GAF B (Fig. 1C–E). This suggests not only that amino acid...

Ngày tải lên: 19/02/2014, 02:20

... no P15692), PDGF-B (accession no. 1109245 A), PDGF-C (acces- sion no AAF80597), PDGF-D (accession no AAK38840), VEGF-A (accession no NP003367) and PIGF-1 (accession no. 1FZV). Red, squared areas ... Cystine Knot Database (http://hormone.stanford.edu/cystine-knot). This review focuses on the structure and function of the two novel members, PDGF-C and -D, of the PDGF subfamily of the...

Ngày tải lên: 19/02/2014, 07:20

... Sys- tem II. ResBC is able to attach heme to monoheme c-type cytochromes c 550 from Paracoccus denitrificans and c 552 from Hydrogenobacter thermo- philus, both normally matured by System I. The production ... and CcdA [12,13] (Fig. 1). Notably, the genomes of some Bordetella species, e.g. B. parapertussis, encode both Systems I and II [1]. In common with System I, it is not clear whether heme...

Ngày tải lên: 06/03/2014, 09:22

... Psy1 and Psy2 relative tran- script contents were normalized onto the 18S rRNA (endogenous reference) transcript contents and com- pared to normalised petal transcript content (calibra- tor), ... contents were normalized onto the endogenous refer- ence transcript (18S rRNA) to account for differences in the amount of total RNA content among samples and com- pared with the normalised transcrip...

Ngày tải lên: 07/03/2014, 05:20

... amino acids or other keto acids on hKAT-I catalyzed KYNA formation. Analysis of substrate specificity revealed t hat a number of amino acids a nd a-keto acids can serve as the amino group donor ... Guidetti, P., Okuno, E. & Schwarcz, R. (1993) Characterization of human b rain k ynurenine aminotransferases using [ 3 H]kynurenine as a substrate. Neuro scienc e 55, 177–184. 26. Okuno, E.F .,...

Ngày tải lên: 07/03/2014, 16:20

... S, Notarangelo LD & Samelson LE (1999) Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal ... association of LAT with phosphatidylinositol 3-kinase and phospholipase C-c following CD2 stimu- lation. Eur J Immunol 32, 2188–2198. 145 Umehara H, Inoue H, Huang J, Kono T, Minami Y, Tanaka Y, Ok...

Ngày tải lên: 18/02/2014, 04:20

... falciparum genome in 2002, new opportunities for research have arisen [15]. The P. falciparum genome has 14 chromosomes, a linear mitochondrial genome and a circular plastid-like genome [15,16]. ... compounds tested, including daunorubicin and nogalamycin, is lowest for helicases from P. falciparum compared with the other helicases [29,30]. It is interesting to note that inhibition by nogalam...

Ngày tải lên: 18/02/2014, 16:20