... affect the rate of transcription[33], and ever since the clear demonstration of a causalrelationship between hypermethylation of the promoter of tumor suppressor genes and the development of cancer, ... in the uniqueN-terminus, (b) binding of the N-terminus by ancillaryfactors, (c) the lack of a negatively functioning modulethat is present in the N-terminus of SAF-1 [26], or (d)all of the ... consensus TATA box.Another notable feature of the two SAF promoters is the presence of a high frequency of CpG dinucleotides,which are also known as CpG islands. The CpGislands have been shown...