Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx

... within the mitochondrial matrix, the location of the exposed thiols on the surface of proteins may also prevent oxidative damage to the proteins on which they are located. To do this, the exposed thiol ... which contrasts with the matrix concentration for exposed protein thiols of 60–90 mm. Therefore, within the mitochondrial matrix, exposed cysteine...

Ngày tải lên: 06/03/2014, 09:22

... migra- tion and differentiation. Studies with knockout mice demonstrate that a main function of AP-2s is the suppression of terminal differentiation during embryonic development. Additionally, the ... migration of undifferentiated mesenchymal cells to regions determined to differenti- ate into bone, followed by aggregation and the forma- tion of mesenchymal condensation [48,49]. The...

Ngày tải lên: 16/02/2014, 09:20

... kaouthia. Considering that the two toxins display 11 residue differences and that the competition systems used (human and rat on one hand, and chicken on the other) are not identical in the two ... subgroup may exert a highly similar biological function. This may be in contrast to the Wntxs from the second subgroup, which display many deviations and few conserved...

Ngày tải lên: 21/02/2014, 03:20

... phosphorylation on the one hand, and the specific and versatile regulation of protein activation required in signaling pathways on the other. Results Mathematical model We consider a target protein ... strongly nonlin- ear through the nonlinear dependence of the effective rate constants (Eqn 3) on the enzyme concentrations and the conservation relations (Eqn 4). T...

Ngày tải lên: 07/03/2014, 10:20

... replication fork differing in the gap sizes of the lagging strand. The gaps in the RF2, RF3 and RF4 are 8, 4 and 0 bp, respectively. As shown in Fig. 7C, DmGEN cleaved the lagging strand of the model ... representation of the conserved N and I domains of some members of the RAD2 ⁄ XPG family. The total number of amino acids in each protein and homology (% identit...

Ngày tải lên: 07/03/2014, 10:20

... phosphoryl- ated. These residues correspond to positions 16 and 32 in the sequence of the mature CP29 (Table 1). The third peptide contained one threonine and three serine residues (Fig. 3C). However, the ... reinhardtii cells exposed to State 2 conditions. The b (N-terminal) and y (C-terminal) fragment ions are labelled and the peptide sequences shown. The lower...

Ngày tải lên: 07/03/2014, 21:20

... Two five-stranded b-sheets are formed at the dimerization interface, each containing four strands from one monomer and the fifth from the other. Residues not fully conserved in LC8 paralogs and orthologs are ... the motif are the most conserved Gln 0 , the flanking Thr+1 and Thr)1 residues and Asp)4 (Fig. 1C). We depict 11 residues both on the logo and in Ta...

Ngày tải lên: 14/03/2014, 22:20

... administration The time-course variation of the relative concentrations of C/EBPa mRNAandproteinwasmonitoredintheratliver. In parallel we also followed the accumulation of the CYP3A1 mRNA, upon addition ... B and C denotes the position of the C/EBP containing complex and the arrowhead ÔssÕ the position of the DNA protein complex shifted by the specific antibody. Ó FEBS...

Ngày tải lên: 17/03/2014, 09:20

... 2005 FEBS 1581 We then assessed the effect of overexpression of dUSP on the transcriptional activation pathways that are induced by 20OHE alone and on the interaction of JH III and 20OHE. In order ... antibody against dUSP or a monoclonal antibody against the unrelated protein ELAV [47]. The antibody was added 30 min before addition of the probe. After incubation a...

Ngày tải lên: 23/03/2014, 13:20

... sequence and deduced amino acid sequence of the toxophallin. The amino acid translation is under the second nucleotide of the corresponding codon. The masses of underlined peptides correspond to the ... treatment and cell death did not depend on the activation of the caspase cascade [16]. The most pronounced destructive changes, namely condensation of nuclear chromatin...

Ngày tải lên: 29/03/2014, 08:20