... Most of these contacts arewith the binding cavity in the Fv domain. However, thereare significant additional contacts to the bottom of the nextFab (cf. Figure 10). The surface covered by the nonbindingbottom ... less to the ligand. The C-terminal part of the pe ptide (RPAP) has clo se contacts to the n ext protein in the crystal cell and is therefore stabilized on the surface o f SM3. It is unclear whether ... cases, the first sugar added,N-acetyl galactosamine is not extended, or is sialylated to form the cancer- related sialyl Tn epitope. Because of the shorter side chains, the peptide core of the cancer...