... Structural energetics of peptide recognition:angiotensin II ⁄ antibody binding. Proteins 15, 113–120.46 Bolen DW & Baskakov IV (2001) The osmophobiceffect: natural selection of a thermodynamic ... University of Texas Medical Branch, Galveston, TX, USA2 Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USAChemokines constitute the largest family of ... the foldedstate of the protein, and that the binding affinity of IL-8 for the N-domain is higher in osmolytes [24]. Inthis study, we have characterized the thermodynamic basis of IL-8 binding...