Báo cáo khoa học: Influence of inflammation-related changes on conformational characteristics of HLA-B27 subtypes as detected by IR spectroscopy potx

... Influence of inflammatory environment on HLA-B27 FEBS Journal 278 (2011) 1713–1727 ª 2011 The Authors Journal compilation ª 2011 FEBS 1727 Influence of inflammation-related changes on conformational ... conformation by B*2709, but in an exceptional dual conformation by the AS- associated B*2705 subtype. One of the conformations observed in B*2705:pVIPR is identical to t...

Ngày tải lên: 06/03/2014, 00:21

... b-carotene 15,15¢-monooxygenase ( NP_059125) was used as the outgroup of the tree. Western blot analysis Briefly, protein concentration was measured by the Brad- ford assay [53]. Equal amounts of protein ... requires atRE as its intrinsic substrate. The isomerohydrolase activity of zebrafish RPE65c is dependent on iron Because zebrafish RPE65c contains the conserved His residues th...

Ngày tải lên: 14/02/2014, 14:20

... structurally conserved regions, such as a-helices or b-sheets, whereas some are posi- tioned in the connecting loops. Approximately one- third of all mutations in the BTK gene are missense and some of these ... also as the overall number of muta- tions increases. Of the residues affected by missense mutations, proline residues are over-represented, pre- sumably secondary to the...

Ngày tải lên: 14/02/2014, 18:20

... August 2007) doi:10.1111/j.1742-4658.2007.06100.x Volume changes of mammalian cells as induced by either anisoosmolarity or under isoosmotic conditions by hormones, substrates and oxidative stress critically contribute to the regulation of metabolism, ... acidification by activation of vacuolar-type H + -ATPase, probably driven by an increase in intracellular Cl – concentrati...

Ngày tải lên: 18/02/2014, 16:20

... spectra of the c ring taken under various laser desorption conditions. Under ultrasoft desorption conditions (A), the c ring is detected unfragmented with a charge distribution of one to four as indi- cated ... variation in c ring subunit composition depending on the growth condi- tions, cells were grown under autotrophic conditions (ATP synthase required) or heterotrophic fermentin...

Ngày tải lên: 18/02/2014, 17:20

... are reports on its functions in opposite directions in the BMP pathway. The function of Tsg as a BMP antagonist is repor- ted to be conserved in Xenopus and zebrafish [30–32]. Injection of antisense ... gradient. In the third phase, dorsoventral patterning is carried out by BMP signa- ling, which is mediated by Smad1. By contrast to the second phase, dorsoventral patterning is in...

Ngày tải lên: 19/02/2014, 00:20

... column. Elution of the major integral membrane proteins from the column was monitored by SDS ⁄ PAGE of every second fraction and subsequent Coo- massie staining of the gels. To raise mono-specific ... Triton X-114 solution. J Biol Chem 256, 1604–1607. 24 Pryde JG & Phillips JH (1986) Fractionation of mem- brane proteins by temperature-induced phase separation in Triton X-114. A...

Ngày tải lên: 19/02/2014, 07:20

... In addition, increased transcription of mitochond- rial genes has been observed as the result of permanent activation of some components of Ca 2+ signaling pathways [13,14,24]. Based on this, ... capacity of muscles is also affected by physiological conditions, such as chronic exercise or contraction activity. Increased oxidative capacity of muscles is normally associated...

Ngày tải lên: 19/02/2014, 07:20

... vector, based on the Moloney murine leukemia virus, to generate a replication-deficient recombin- ant retrovirus containing the deoxyribonucleoside kinase cDNA of Drosophila melanogaster. Oligonucleotide ... function of nucleoside kinases is to provide the cells with deoxyribonucleo- tides for DNA replication and repair. DNA replication is tightly controlled to avoid the introduction of...

Ngày tải lên: 20/02/2014, 01:20

... verbal irony. We also show that the recognition of human targets poses additional challenges on mining opi- nions from UGC, since they are frequently mentioned by pronouns, definite descrip- tions ... use of irony and negative opinions? Finally, approaches to opi- nion mining have implicitly assumed that the prob- lem at stake is a balanced classification problem, based on the...

Ngày tải lên: 20/02/2014, 05:20