... actin-binding proteins that share a number of repeateddomains; six in the case of gelsolin itself, adseverin and villin, and three in capG, fragmin and severin (for a review,see [2]). The binding ... Co-operation of domain-binding and calcium-binding sites in the activation of gelsolinEmeline Lagarrigue1, Sutherland K. Maciver2, Abdellatif Fattoum3, Yves Benyamin1 and Claude Roustan11UMR ... coupling of the two calcium binding sites within G2 and G6. Additional calcium binding in other domains thenresult in the complete opening and activation of thegelsolin molecule.Keywords: actin;...